硫普罗宁抗急性肝损伤的实验研究  

EXPERIMENTAL STUDY ON THE EFFECT OF TIOPRONIN IN PROTECTION OF ACUTE LIVER INJURY IN RATS

作　　者：杜荔菁[1] 唐望先[1] 张文英[1] 李绍白[1] 

机构地区：[1]同济医科大学附属同济医院肝病研究所

出　　处：《中国新药杂志》1998年第6期472-474,共3页Chinese Journal of New Drugs

摘　　要：目的：用Ｄ氨基半乳糖（ＤＧａｌＮ）制备大鼠急性肝损伤模型。方法：通过检测血清ＡＬＴ及各种细胞因子包括：肿瘤坏死因子α（ＴＮＦα）、白细胞介素６（ＩＬ６）和白细胞介素８（ＩＬ８）浓度的变化，并观察光镜和电镜下肝组织的病理改变，以探讨硫普罗宁对急性肝损害的保护作用。结果：模型组ＡＬＴ、ＴＮＦα、ＩＬ６及ＩＬ８显著升高；而硫普罗宁组ＡＬＴ及以上各细胞因子的水平均较模型明显降低（Ｐ＜００１）。结论：硫普罗宁可能通过免疫机制的调节，降低ＴＮＦα、ＩＬ６及ＩＬ８等细胞因子的生成和释放。OBJECTIVE:To explore the effect of tiopronin in protection of acute liver injury in rats.METHODS:Acute liver injury model in rats was induced by D galactosamine,and the serum level of cytokines determined in conjunction with microscopic and electron microscopic observations on pathological changes in liver were used to evaluate the liver protection effect of tiopronin.RESULTS:The serum concentration of cytokines,such as ALT,TNF α,IL 6,and IL 8,in active and control groups were obtained,and the level of cytokines in active group were significantly reduced in comparation with those of control group.CONCLUSION:It can be concluded that tiopronin possesses obvious protection effect on acute liver injury in rats model in terms of inhibition of TNF α,IL 6 and IL 8 .

关 键 词：硫普罗宁 肝损害 细胞因子 治疗 药理 

分 类 号：R575.05[医药卫生—消化系统]