肿瘤抑制基因异常甲基化与胃癌的研究进展  

Research Development of Aberrant Methylation of Tumor Suppressor Gene in Gastric Tumor

作　　者：魏国华[1] 高志安 

机构地区：[1]辽宁医学院病理学教研室,辽宁锦州121001

出　　处：《辽宁医学院学报》2009年第6期554-557,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：辽宁省自然科学基金;编号:002073

摘　　要：表遗传学是研究在DNA序列没有改变的情况下,所发生的可遗传性基因表达的改变,其中DNA甲基化是研究最多、最深入的一种表遗传学表达机制。CpG岛是人类基因组中富含CpG二核苷酸的DNA序列,主要位于基因启动子区,大小约为100～1 000 bp,与约60%的编码基因相关。DNA中CpG岛甲基化可导致抑癌基因的表观遗传学转录失活,直接参与肿瘤的发生机制。我们简要综述了DNA甲基化在胃癌中的研究进展。Epigenetics is the study of genetic changes in gene expression without the sequence change of DNA,in which DNA methylation is one of the most widely studied epigenetic mechanism.CpG island is the sequence of human genome,located mainly in the promoter as well as the first extron regions.The size of it is nearly 100-1000 bp and it links with 60%of human coding genes. Methylation of CpG sites in the promoter regions of genes can lead to decreased expression and silence the tumor suppressor genes and contribute to oncogenesis.The research development of DNA methylation in gastric carcinoma was reviewed in this article.

关 键 词：肿瘤抑制基因 DNA甲基化 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]