食管鳞癌组织中IGF-1R、VEGF-C的表达变化及意义  

Expression and siginficance of IGF-1R and VEGF-C in esophageal squamous cell carcinoma

作　　者：李峰[1] 俞力超[1] 蒋志华[1] 施舜缤[1] 

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《山东医药》2010年第2期30-31,共2页Shandong Medical Journal

基　　金：镇江市社会发展基金资助项目(SH2008033);江苏大学医学发展基金资助项目(JLY20080044)

摘　　要：目的观察食管鳞癌组织中的胰岛素样生长因子-1R(IGF-1R)、血管内皮生长因子C(VEGF-C)的表达变化,并探讨其意义。方法分别采用免疫组化法、免疫印迹法检测食管鳞癌和癌旁正常食管组织中的IGF-1R、VEGF-C。结果食管鳞癌组织中IGF-1R、VEGF-C阳性率分别为81.05%、67.37%,癌旁组织中分别为20%、5%,P均<0.01;食管鳞癌组织中IGF-IR、VEGF-C蛋白条带灰度比值分别为0.58±0.03、0.43±0.05,癌旁组织中分别为0.43±0.02、0.31±0.04,P均<0.05。IGF-IR、VEGF-C表达与食管鳞癌淋巴结转移、浸润深度有关(P均<0.01),二者表达呈正相关(r=0.29,P<0.05)。结论食管鳞癌组织中IGF-IR、VEGF-C高表达,在食管鳞癌的发生发展及转移中有重要作用。Objective To detect the expression of IGF-I R and VEGF-C in esophageal squamous cell carcinoma （ ES- CC） ,and investigate its sigiidlcance. Methods The expression of IGF-1R and VEGF-C on tumor tissues from 95 ESCC patients and 40 non-cancer tissues were detected by immunohistoehemistry. The expression of IGF-1R and VEGF-C on tumor tissues from 20 ESCC patients and 20 non-cancer tissues were detected by Western-blot. Results The positive fren- quency of IGF-1R and VEGF-C in ESCC were 81.05 % （77/95） , 67.37 % （ 64/95 ） respectively. And the expression of those in non-cancer were 20.00 % （8/40） , 5.00 % （2/40）. There was statistical significance between cancer and noncancer （P 〈 0.01 ）. The positive frenqueney of IGF-1R and VEGF-C in ESCC were 0. 58±0.03 、0.43±0.05 respectively by Western-blot （ P 〈0. 05 ）. The expression rate of IGF-1R was strongly associated with VEGF-C （ P 〈 0. 05 ）. Conclusion Expression of IGF-1R and VEGF-C raise in ESCC. Both of them may play important roles in the occurrence ,development and metastasis of ESCC .

关 键 词：食管肿瘤 鳞状细胞癌 胰岛素样生长因子 血管内皮生成因子 

分 类 号：R735.2[医药卫生—肿瘤]