结外鼻型NK/T细胞淋巴瘤的临床治疗与预后分析  

Prognostic factors and treatment outcome in 56 cases of extranodal nasal NK/T-cell lymphoma

作　　者：罗杨坤[1] 谭燕[1] 郎锦义[1] 彭瑛[1] 王捷[1] 文浩[1] 

机构地区：[1]四川省肿瘤医院放射治疗中心,四川成都610041

出　　处：《西部医学》2010年第1期123-125,共3页Medical Journal of West China

摘　　要：目的分析结外鼻型NK/T细胞淋巴瘤的疗效与预后因素。方法对经病理学证实的56例结外鼻型NK/T细胞淋巴瘤患者的临床资料进行总结,并分析预后因素。单因素分析采用Kaplan-Meier法,多因素分析采用Cox比例风险模型。结果全组3、5、10年生存率分别为51.2%、48.1%和42%。放疗和放化疗的5、10年生存率分别是60.1%、38.2%和50.2%、34.2%,没有统计学意义。达到和未达到CR的5年生存率分别为65.2%和18.8%,具有统计学意义。多因素分析,B症状,颈淋巴结肿大及近期疗效为独立预后因素。结论放化疗与放疗相比较不能提高生存率。B症状,颈淋巴结肿大及近期疗效为独立预后因素。Objective To retrospectively study the treatment outcome and prognostic factors of 56 cases of extran- odal nasal NK/T-cell Lymphoma. Methods 56 patients with pathologically confirmed extranodal nasal NK/T-cell Lymphoma were analyzed. Kaplan Meier methods were applied in unifactorial analysis, and the Cox regression model was ap- plied in multivariate analysis. Results The 3, 5 and 10 -year survival rate were 51.2%, 48.1% and 42%, respectively. The 5 and 10 year survival rate of patients treated by radiotherapy and radiotherapy combined with chemotherapy were 60. 1% and 38.2%, and 50. 2% and 34.2%. The 5-year survival rate for CR and no-CR patients were 65.2% and 18. 8% （P〈0. 01）. Multivariate analysis by COX regression showed that B symptoms, Regional Lymphadenopathies, in- itial treatment response were independent prognostic factors . Conclusion Radiotherapy combined with chemotherapy does not improve the survival of patients with extranodal nasal NK/T-cell Lymphoma. B symptoms, Regional Lymphadenopathies, initial treatment response are independent prognostic factors.

关 键 词：放射治疗 化学治疗 预后 鼻型NK/T细胞淋巴瘤 

分 类 号：R733.4[医药卫生—肿瘤]