清火护肝颗粒对实验性肝炎保护作用的研究  

Protective effects of Yangganqingrekeli on experimental hepatitis

作　　者：高勇[1] 胡宗卫[1] 齐建[1] 

机构地区：[1]辽宁省大连市中医医院,辽宁大连116013

出　　处：《实用中医内科杂志》2010年第1期40-41,共2页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察清火护肝颗粒的抗实验性肝炎作用。[方法]分别采用四氮化碳(CCl_4)和D-半乳糖胺(D-GalN)诱导小鼠发生实验性急性肝损伤。[结果]清火护肝颗粒可对抗四氮化碳和D-半乳糖胺所致血清中ALT、AST、ALP升高及GSH降低,并减轻D-半乳糖胺所致肝脏病变程度,其中以中剂量(相当于生药80g/Kg)预防给药7d效果最佳。[结论]清火护肝颗粒对实验性肝炎有保护作用。[ Objective ] To study the protective effects of Yangganqingrekeli on experimental hepatitis. [ Method] Mice acute liver injury model was induced by CCl4or D - galactosamine （ D - GL）. [ Result] The decrease of ALT, AST, ALP, and the increase of GSH inserum which were induced by CCl4 or D - GL could be resisted by Yangganqingrekeli, the hepato - cellular degeneration and necrosis induced by D - GL could also be diminished. The best dosage is （80g .kg^-1/d,7d, ig）. [ Couclusion] Pretreatment with Yangganqingrekeli moderately prevents the liver damage induced by CCl4 or D - GL.

关 键 词：实验性肝炎 清火护肝颗粒 D-半乳糖胺 四氯化碳 

分 类 号：R-33[医药卫生]