Stat3、Survivin和Bcl-2在胃癌组织中的表达  

Expression of Stat3,Survivin and Bcl-2 in Gastric Cancer

作　　者：孙莹[1,2] 吴荒[3] 王波[1] 张灵[1] 赵雪俭[1] 

机构地区：[1]吉林大学前列腺疾病防治研究中心白求恩医学院病理生理教研室,吉林长春130021 [2]吉林大学第一医院 [3]吉林大学第二医院

出　　处：《中国实验诊断学》2010年第1期73-75,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金项目(30801354);吉林省科学技术厅青年基金(20080154)

摘　　要：目的探讨Stat3、Survivin和Bcl-2在胃癌组织中的表达情况。方法对42例胃癌组织和19例正常胃组织采用免疫组织化学方法分析,采用Mann-Whitney U法分析组间差异。结果胃癌组中Stat3、Survivin和Bcl-2表达阳性的分别有31例、29例和25例,正常组Stat3、Survivin和Bcl-2表达阳性的分别有2例、0例和3例,三者在两组间均存在统计学差异(P<0.01)。结论胃癌组织中Stat3、Survivin和Bcl-2表达上调,可能与肿瘤的发生和发展相关。Objective To explore the expression of Star3, Survivin and Bcl-2 in Gastric Cancer. Methods 42 gastric cancer samples and 19 normal gastric samples were detected by immunohistochemical staining. Mann-Whitney U analysis was used to detect the difference between two groups.Results Stat3,Survivin and Bcl-2 expressed in 31,29,25 gastric cancer cases and expressed in 2,0,3 normal tissues respectively.Significant difference was found in three factors between two groups （ P 〈 0.01 ）. Conclusion The expression of Stat3, Survivin and Bcl-2 were upregulated in gastric cancer tissues, and they may be involved in the occurrence and development of the tumor.

关 键 词：胃癌 STAT3 SURVIVIN BCL-2 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]