脑卒中患者IL-18及CRP血清水平检测分析  

Analysis of measured serum levels of IL-18 and CRP in patients with cerebral stroke

作　　者：潘云[1] 唐任光[1] 黄建敏[2] 韦叶生[1] 

机构地区：[1]广西右江民族医学院附属医院检验科,广西百色533000 [2]广西右江民族医学院附属医院神经内科,广西百色533000

出　　处：《中国实验诊断学》2010年第1期93-95,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助项目(No:30660159)

摘　　要：目的探讨脑卒中患者血清白细胞介素18(Interleukin-18.IL-18)及C-反应蛋白(C-reactiveprotein,CRP)含量变化的临床意义。方法将98例脑卒中患者分为脑梗死组(52例),脑出血组(46例),同期选择健康体检者38例为对照组,分别检测其治疗前和治疗后5天的血清IL-18和CRP的浓度。根据神经功能损伤程度评分标准将患者分为轻度损伤组(32例)、中度损伤组(46例)和重度损伤组(20例)。结果脑卒中患者治疗前血清IL-18及CRP明显高于对照组(P<0.05),且治疗后比治疗前明显下降(P<0.05),并随着脑神经功能损害的加重而升高(P<0.05)。结论IL-18及CRP在脑卒中发病过程中起促进作用,与脑神经受损程度相关。Objective To investigate the changes chnical significance of serum levels of IL-18 and CRP in patients with cerebral stroke. Methods The serum levels of IL-18 and CRP were determined in 52 cases of cerebral infarction and 46 cases of cerebral hemorrhage before, and 5 days after＇the treatment and 38 healthy subjects. Based on the scoring of neurologic impairment degree ac- cording to standards mild impairment group included 32 cases, moderate impairment group included 46 cases and severe impairment group included 20 cases. Results Compared with control group, the IL-18 and CRP levels in patients with cerebral infarction or cere- bral hemorrhage were much higher before treatmeni, it decreased after treatment and increased with aggravation of cerebral nerve dys- function. Conclusion the IL-18 and CRP may playpromotive role in the pathogenesis of ischemic stroke, and related to nerve dys- function progression.

关 键 词：脑卒中 白细胞介素18 C-反应蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]