pRb2/P130与CDK4蛋白在子宫内膜腺癌中的表达及意义  

Expression and significance of pRb2/P130 protein and CDK4 protein in endometrial adenocarcinoma

作　　者：支霜[1] 傅芬[1] 李里香[1] 蔡勇[2] 

机构地区：[1]南昌大学第二附属医院,江西南昌330006 [2]江西省肿瘤医院

出　　处：《中国妇幼保健》2010年第1期109-111,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨pRb2/P130与CDK4蛋白表达与子宫内膜癌的发生、发展的关系。方法:应用免疫组化S-P法检测pRb2/P130、CDK4在28例正常增生期子宫内膜组织、20例不典型增生子宫内膜、30例子宫内膜腺癌组织中的表达程度,并分析它们之间的关系。结果:pRb2/P130蛋白在正常增生期子宫内膜、不典型增生子宫内膜、子宫内膜腺癌组织中的阳性表达率依次递减,而CDK4的阳性表达率依次递增,子宫内膜腺癌和不典型性增生中pRb2/P130阳性表达率明显低于正常增生期子宫内膜,差异均有统计学意义(P<0.05),而CDK4的阳性表达率明显高于正常增生期子宫内膜,差异均有统计学意义(P<0.05)。pRb2/P130阳性表达缺失与组织学分级有关(P<0.05),与子宫肌层浸润程度无关(P>0.05);CDK4阳性表达与子宫内膜腺癌肌层浸润深度有关(P<0.05),而与肿瘤的组织学分级和临床分期无关(P>0.05)。pRb2/P130蛋白表达与CDK4呈负相关(P<0.05)。结论:子宫内膜腺癌中存在pRb2/P130蛋白表达下降或缺失及CDK4的异常表达,促进了细胞的生长和肿瘤的发展,是子宫内膜腺癌的发生、发展中的重要事件。Objective： To explore the relationship between the expression of pRb2/P130 protein and eyclin dependent kinase 4 （CDK4） protein and the oncogenesis and development of endometrial adenocarcinoma. Methods： The expression levels of pRb2/P130 protein and CDK4 protein were examined by immunohistochemical S - P method in 28 cases with normal endometrial tissues at proliferative stage, 20 cases with endometrial tissues of atypical hyperplasia and 30 cases with endometrial adenocareinoma, and the relationship among them was analyzed. Results： The positive rate of pRb2/P130 protein decreased gradually from normal endometrial tissues at proliferative stage, endometrial tissues of atypical hyperplasia to endometrial adenocarcinoma, while the positive rate of CDK4 increased gradually; the positive rates of pRb2/P130 protein in endometrial tissues of atypical hyperplasia and endometrial adenocarcinoma were lower than that in normal endometrial tissues at proliferative stage （ P 〈 0.05 ）, while the positive rate of CDK4 reversed （ P 〈 0. 05 ） . There was a correlation between positive rate of pRb2/P130 and histological grade （P 〈 0. 05 ） , but there was no correlation between positive rate of pRb2/P130 and myometrial invasion of uterus （P 〉 0. 05） ; there was a correlation between positive rate of CDK4 and myometrial invasion of uterus （ P 〈 0. 05 ） , but there was no eorrelation between positive rate of CDK4 and histologieal staging and clinical grade （ P 〉 0. 05 ） . There was a negative correlation between pRb2/P130 protein expression and CDK4 expression （P 〈 0. 05 ） . Conclusion： Low expression level of pRb2/ P130 protein and abnormal expression of CDk4 in endometrial adenocarcinoma can promote the oncogenesis and development of endometrial adenocarcinoma.

关 键 词：子宫内膜癌 免疫组织化学 PRB2/P130 CDK4 

分 类 号：R737.33[医药卫生—肿瘤]