肿瘤坏死因子与儿童中枢神经系统白血病  

TUMOR NECROSIS FACTOR IN THE CEREBROSPINAL FLUID OF CHILDREN WITH CENTRAL NERVOUS SYSTEM LEUKEMIA

作　　者：胡群[1] 刘双又[1] 郭艺杰[1] 彭光洁[1] 

机构地区：[1]同济医科大学附属同济医院儿科,430036

出　　处：《中国小儿血液》1998年第2期73-75,共3页China Child Blood

摘　　要：用酶联免疫法检测了25例儿童急性白血病（A组：8例，伴中枢神经系统白血病，B组：17例，不伴中枢神经系统白血病）脑脊液（CSF）中肿瘤坏死因子（TNF）及其与CSF各化验指标的相关性，结果示：A组病人CSF中TNF为10．06士13．50ng／ml，较B组（1．1士0．42ng／ml）升高，差异有显著意义（P＜0．01），CSF中TNF的升高与CSF细胞数及蛋白呈正相关（r=0．6807，0．6764，P＜0．05），与CSF糖无相关性，A组中三例病人动态观察的结果示随治疗后症状改善，TNF也下降。The tumor necrosis factor(TNF) in cerebrospinal fluid (CSF) of children with leukemia were detected by ELISA. The patients were divided into two groups: group A (n=8): patients with central nervous system leukemia (CNSL), group B (n = 17): patients with no CNSL. The results show that TNF in CSF was significantly higher in group A (10. 06±13.50ng/ml) than that in group B (1. 1 ±0. 42ng/ml), P<0. o1. Higher TNF levels in CSF are correlated with cell counts and protein in CSF (r= 0. 6807, 0. 6764,P<0. 05), not correlated with sugar levels in CSF. TNF in CSF decreased gradually with intrathecal chemotherapy in three children with CNSL.

关 键 词：肿瘤坏死因子 中枢神经系统 白血病 儿童 

分 类 号：R733.7[医药卫生—肿瘤]