盐酸头孢吡肟合成路线图解  

Graphical synthetic routes of cefepime hydrochloride

作　　者：王志贤[1] 张海波[1] 陈言德[1] 

机构地区：[1]扬子江药业集团有限公司泰州新药研究院,江苏泰州225321

出　　处：《中国医药导报》2010年第2期17-18,共2页China Medical Herald

摘　　要：本文综述了第四代注射用头孢菌素盐酸头孢吡肟的合成路线,主要是以3-氯代甲基头孢菌素或7-氨基-3-乙酰甲氧基-头孢-3-烯-4-羧酸(7-ACA)为起始原料有2条合成路线,两种方法各有优势,在生产中可根据实际情况来选择适合的路线。Graphical synthetic mutes of the fourth generation injectable cephalosporin cefepime hydrochloride are re- viewed in this article, mainly based on 3-chlom-methyl cephalosporins, or 7-amino-3-acetyl-methoxy-cephalosporin-3- en-4-carboxylic acid （7-ACA） as the starting material with two synthetic routes, both methods have advantages in the production of the actual situation can select the appropriate line.

关 键 词：盐酸头孢吡肟 合成路线 图解 

分 类 号：R978.1[医药卫生—药品]