头颈部恶性肿瘤患者血小板聚集性的电镜观察  

Observation on platelet aggregative ability in patients with malignant tumors of head and neck by electron microscope

作　　者：郑芸[1] 梁传余[1] 

机构地区：[1]华西医科大学附属第一医院耳鼻咽喉科

出　　处：《中华耳鼻咽喉科杂志》1998年第5期270-271,共2页Chinese Journal of Otorhinolaryngology

摘　　要：目的探讨头颈部恶性肿瘤与血小板聚集性的关系。方法采用电镜方法，以血小板聚集型百分比为指标，检测了３７例头颈部恶性肿瘤患者的血小板聚集性，并以非肿瘤患者和良性肿瘤患者各１０例作为对照。随访了手术后４～６个月的２５例头颈部恶性肿瘤患者的血小板聚集性的改变值。结果①头颈部恶性肿瘤患者的血小板聚集型百分比均数显著高于非肿瘤患者和良性肿瘤患者（Ｐ值均小于０．０５）；②头颈部恶性肿瘤患者血小板聚集型百分比随临床分期进展而显著增高（Ｐ＜０．０５）；③手术后４～６月的随访患者中，１７例无转移和无复发患者的血小板聚集型百分比较手术前显著降低（Ｐ＜０．０５）；８例有转移或有复发患者的血小板聚集型百分比则较手术前显著增高（Ｐ＜０．０５）。结论①头颈部恶性肿瘤患者的血小板聚集性增加；②电镜方法测定的血小板聚集型百分比在判断头颈部恶性肿瘤的发展、疗效和预后上可能有潜在的价值。Objective To investigate the relationship between the platelet aggregative ability and malignant tumors of head and neck. Method Platelet aggregative ability was detected by electron microscopy (EM) in 37 patients with malignant tumors of head and neck(Group C), 10 patients with non neoplastic diseases(GroupA) and 10 patients with benign tumors of head and neck(Group B) as the control group, with the ratio of aggregative type platelets as the index. Twenty five of 37 patients with malignant tumors except 8 cases of nasopharyngeal carcinoma were included in the follow up study 4 6 months after operations. Results ①The mean ratio of aggregative type platelets in patients from Group C was significantly higher that that of Group A or Group B patients ( P <0.05);②In Gronp C , the mean ratio of aggegative type platelets inereased significantly with the development of clinical staging( P <0.05);③In follow up study, the mean ratio of aggregative type platelets of 17 patients without metastasis and recurrence was significantly lower than that before operation, while the results of 8 patients with metastasis or recurrence was totally opposite. Conclusions ①The aggregative ability of platelets increased in patients with malignant tumors of head and neck;②The ratio of aggregative type platelets detected by EM has an important potential value in judging the development、therapeutic effects and prognosis of the malignant tumors of head and neck.

关 键 词：头颈部肿瘤 血小板聚集 预后 电镜 

分 类 号：R739.910.7[医药卫生—肿瘤]