结直肠癌P170蛋白表达的检测及意义  

Expression of P170 Protein in Colorectal Cancer and Its Significance

作　　者：饶歆[1] 林从尧[1] 冯茂辉[1] 李春光[1] 吴洲清[1] 

机构地区：[1]武汉大学中南医院肿瘤科,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2010年第1期58-60,75,共4页Medical Journal of Wuhan University

基　　金：湖北省自然科学基金资助项目(编号:2008CBD130)

摘　　要：目的:探讨多耐药基因(MDR1基因)的编码产物P170蛋白在人结直肠癌组织中的表达及其意义。方法:利用单克隆抗体流式细胞术检测43例结直肠癌组织和距离肿瘤5 cm以上正常肠黏膜组织P170蛋白的表达。结果:P170蛋白在43例结直肠癌组织与正常组织中表达差别有统计学意义,P170蛋白在癌组织中表达与患者年龄、性别、发病部位、病理类别、分化程度、淋巴转移、远处转移以及病理分期之间差异无统计学意义。结论:结直肠癌组织具有多药耐药性(MDR),而通过流式细胞术检测P170蛋白对于定量评价多药耐药水平具有一定临床指导意义。Objective： To study on the expression of p170 protein in the tissue of colorectal cancer and its significance. Methods： The expression of p170 protein was detected both in carcinoma and normal tissue （〉5 cm away from carcinoma） by use of flow cytometry. Results： The expression of p170 protein in carcinoma had a statistical difference from that in normal tissue. And P170 protein expression has no statistical relation with patient＇s age, gender, site of onset, pathological type, differentiation degree, lymphatic metastasis, distant metastasis, and pathological stage. Conclusion： Multidrug resistance （MDR） exists in colorectal cancer commonly, and it is helpful to evaluate the level of MDR by P170 protein detection by use of flow cytometry.

关 键 词：结直肠癌 P170蛋白 多耐药 流式细胞术 

分 类 号：R735.35[医药卫生—肿瘤]