不同正畸力作用下牙周组织中碱性成纤维细胞生长因子表达的实验研究  

Expressions of bFGF in rabbits' periodontium under different orthodontic forces

作　　者：张燎[1] 诸葛春耕[1] 梅银生[2] 张君[2] 

机构地区：[1]山东省泰安市口腔医院,山东泰安271000 [2]山东大学口腔医学院正畸科,济南250012

出　　处：《山东大学学报（医学版）》2010年第1期34-37,共4页Journal of Shandong University:Health Sciences

基　　金：山东省泰安科技计划资助项目(2004-52);山东省自然科学基金资助项目(Y2007C023)

摘　　要：目的探讨不同正畸力作用下兔牙周组织中碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)的表达与分布及其在正畸牙移动过程中的作用和机制。方法建立兔正畸牙移动模型,实验组分别施加10、50、100g力,1周后将动物处死,制备左侧上颌第一磨牙及牙周组织的标本,进行免疫组化染色(HI-SABC法)后检测、分析,并与对照组比较。结果对照组bFGF染色呈弱阳性,受力10g组与对照组间差异无统计学意义,受力50g组与对照组相比差异有统计学意义,受力100g组与对照组间差异无统计学意义,其余两两比较差异无统计学意义。结论在适宜的矫治力作用下,牙周组织中bFGF表达增强;bFGF可能参与了正畸牙移动,并促进了正畸牙牙周组织的修复重建。Objective To research expression and distribution of basic fibroblast growth factor （bFGF） in periodontium by establishing orthodontic tooth movement model of rabbits and to analyze the role of bFGF in orthodontic tooth movement. Methods The orthodontic tooth movement model of rabbits was established. 10g,50g and 100g forces were respectively exerted on the three experimental groups until the animals were executed one week later. Then,the first molar and periodontium specimens were taken out,and immunohistochemical staining （HI-SABC method） was performed and the results were compared. Results The staining result of the control group was weakly positive. A significant difference was only found between the 50g force group and the control group among the multiple comparisons. Conclusion Suitable orthodontic force could enhance expression of bFGF in the periodontium. bFGF may participate in orthodontic tooth movement and promote the repairing and rebuilding of the periodontium.

关 键 词：成纤维细胞生长因子 牙周组织 正畸力 兔 

分 类 号：R783.5[医药卫生—口腔医学]