高碘对大鼠凝血功能的影响  

Effect of excess iodine on coagulation function in rats

作　　者：郭雪芹[1] 杨群[2] 张辉[3] 张娟[4] 边建朝[5] 杨晓霞[5] 郭成浩[1] 

机构地区：[1]山东大学医学院病理学与病理生理学研究所,济南250012 [2]山东大学公共卫生学院营养与食品卫生研究所,济南250012 [3]山东大学第二医院耳鼻喉科,济南250033 [4]山东大学齐鲁医院病理科,济南250012 [5]山东省地方病防治研究所,济南250014

出　　处：《山东大学学报（医学版）》2010年第1期45-47,共3页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金资助课题(30772134);山东省科技厅资助课题(2006BS03029)

摘　　要：目的建立高碘喂养的大鼠动物模型,观察不同浓度的高碘对大鼠凝血功能影响的剂量与效应关系。方法实验分4组:①正常饲料+正常水组(NI);②正常饲料+10倍碘组(10HI);③正常饲料+50倍碘组(50HI);④正常饲料+100倍碘组(100HI);每周称体重,饲养6个月,用乙醚麻醉,从眼球静脉取血,CA7000全自动凝血分析仪测定凝血酶原时间(PT-time)、凝血酶原时间国际标准化比值(PT-INR)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原时间(Fbg-time)、纤维蛋白原浓度(Fbg-c)、抗凝血酶Ⅲ活性(AT3:A)和D-二聚体(D-dimer)。结果与NI相比,10HI组的大鼠PT-time、PT-INR、Fbg-time、TT、APTT和AT3:A数值降低(PT、PT-INR、Fbg-time、AT3:A:P<0.05;TT、APTTP<0.01),Fbg-c数值升高(P<0.01);而50HI和100HI组的大鼠PT-time、PT-INR、Fbg-time、TT、APTT数值升高(50HI组的Fbg-time、TTP<0.05;50HI、100HI组的其它指标P均<0.01),Fbg-c数值降低(50HI组:P<0.05,100HI组P<0.01)。结论适量高碘对大鼠凝血功能有促进作用,但是随着碘浓度升高,凝血功能降低。Objective To observe the dose-effect relation between excess iodine and coagulation function in rats. Methods Wistar strain rats were divided into four groups：the normal diet and water group（NI）,the normal diet and 10-fold iodine group（10HI）,the normal diet and 50-fold iodine group（50HI）,and the normal diet and 100-fold iodine group（100HI）. Body weights were determined weekly. After 6 months,blood was taken from the eyeball vein and then PT-Time,PT-INR,APTT,TT,Fbg-Time,Fbg-c,AT3：A,and D-dimer were determined by the Sysmex CA7000 automated blood coagulation analyzer. Results PT,PT-INR,Fbg-time,TT,APTT,and AT3：A were decreased while the number of Fbg-c was significantly increased in the 10HI group compared with the NI group（PT,PT-INR,Fbg-time,AT3：A：P〈0.05：TT,APTT,Fbg-c：P〈0.01）. PT-time,PT-INR,Fbg-time,TT,and APTT significantly increased while Fbg-c significantly decreased in the 50I and 100I groups comparing with the normal control group （except for Fbg-Time,TT and Fbg-c in the 50HI group P〈0.05; the other blood coagulation indexes in the 50 HI and 100 HI groups,P〈0.01）. Conclusion Appropriate excess iodine can promote blood coagulation of rats,however,with an increase of concentration of iodine,blood hypocoagulability is decreased.

关 键 词：碘 过量 凝血功能 大鼠 Wistar 

分 类 号：R364.1[医药卫生—病理学]