胶原基纳米骨加自体骨修复颌骨缺损的研究  

Repairing jaw defects with mixture of nano-hydroxyapative/collagen composite and autogenous chip bone

作　　者：张昊[1] 张丽军[1] 韩志峰[1] 吴燕丽[1] 朱菲[1] 姚丽[1] 徐文[1] 刘莹[1] 

机构地区：[1]北京市和平里医院口腔科,北京100013

出　　处：《中国骨质疏松杂志》2010年第1期23-26,共4页Chinese Journal of Osteoporosis

基　　金：首都医学发展科研基金资助项目(首都2005-3067)

摘　　要：目的观察胶原基纳米骨(nHAC)加自体骨修复颌骨缺损的临床效果。方法选择颌骨缺损需植骨者,随机分为3组,分别填入nHAC加自体骨(63例),骨诱导活性材料(OAM)(44例)以及单纯nHAC(57例)3组不同植骨材料。术后1、2、3、4、6、8、12个月复诊,对病损部位进行临床及X线检查,观察新骨形成情况。结果nHAC加自体骨、OAM、nHAC充填修复颌骨缺损之间疗效无显著差异(P>0.05),X线显示nHAC加自体骨、OAM成骨速度早于单纯nHAC。结论nHAC加自体骨修复颌骨缺损是一种可行的方法,可以提高骨缺损修复的效果。Objective To study clinical effect of the mixture of nano-hydroxyapative/collagen composite （nHAC） and autogenous chip bone in repairing jaw defects. Methods Jaw defects in need of transplanting bone were selected and randomly divided into three groups. Three methods （the mixture of nHAC and autogenous chip hone （ 63 cases） , osteoinduction active material （ OAM ） （ 44 cases） , nHAC （ 57 cases） were used to repair the jaw defects. After 1, 2,3,4, 6, 8 and 12 months, all cases were checked the condition of new bone formed and calcified by X-ray and clinical examination. Results There were no significant differences of the mixture of nHAC and autogenous chip bone, OAM, nHAC in repairing jaw defects（P 〉 0. 05）. New bone formed and calcified earlier in the mixture of nHAC and autogenous chip bone and OAM than that in nHAC. Conclusion It is feasible to repair jaw defects using the mixture of nHAC and autogenous chip hone. The mixture may promote the reparation of bone defects.

关 键 词：胶原基纳米骨 自体骨 修复 颌骨缺损 

分 类 号：R78[医药卫生—口腔医学]