协同刺激分子B7-H4在恶性肿瘤中的表达意义  

Expression of B7-H4 and Its Significance in Human Malignant Tumor

作　　者：胡文蔚[1] 蒋敬庭[1] 吴昌平[1] 

机构地区：[1]苏州大学第三附属医院肿瘤生物诊疗中心,江苏常州213003

出　　处：《医学综述》2010年第1期52-54,共3页Medical Recapitulate

基　　金：国家自然科学基金(30950022;30972703);常州市社会发展计划(CS2008202;CS20092019)

摘　　要：协同刺激分子B7-H4是B7家族中的一个新成员,它能通过抑制T细胞的增殖、细胞因子的产生和细胞周期负性调控T细胞的免疫应答,同时大量表达B7-H4可以促进上皮细胞的恶性转化,保护表皮细胞免于失巢凋亡,在肿瘤的发生、进展和转归中发挥重要作用。研究B7-H4在恶性肿瘤中的表达及意义对于临床诊断具有重要作用,也为新的分子靶点治疗恶性肿瘤提供新的策略。Costimulatory molecule B7-H4 is a new member of B7 family. It ca, negatively regulate T cells immune response by inhibiting T cell proliferation, cytokine production and cell cycle. Overexpression of BT-H4 plays an important role in initiation, progression and regression of tumor, by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. Study of B7-H4 expression in malignant tumors is useful in clinical diagnosis and treatment, and offers new strategy to pursue for molecule target treatment in cancer.

关 键 词：B7-H4 协同刺激信号 肿瘤 恶性 免疫逃逸 

分 类 号：R730.23[医药卫生—肿瘤]