RNA干扰原理及其在肿瘤研究中的应用  

The Principle of RNAi and Its Application in Tumor Research

作　　者：黄坤寨[1] 蔡建春[1] 

机构地区：[1]福建医科大学附属厦门第一医院肿瘤中心,福建厦门361003

出　　处：《医学综述》2010年第1期72-74,共3页Medical Recapitulate

摘　　要：RNA干扰(RNAi)是一种在动植物中广泛存在的、由双链RNA诱发的、同源mRNA特异性沉默的过程,包括小干扰RNA生成的起始阶段及靶mRNA降解的效应阶段。已成为分子生物学研究中最为活跃的热点之一;在肿瘤研究中,RNAi在抑制肿瘤抗凋亡基因、沉默癌基因、调控细胞周期、抗血管生成、增强放化疗敏感性及基因功能研究等有较广泛的应用。RNA interference（RNAi） ,which is a phenomenon widely existing in animals and plants,is a mRNA-specific silence process, induced by homologous double-stranded RNA, including initial stage（ generation of small interference RNA, siRNA） and effect stage （ degradation of target mRNA）. RNAi has been one of the most active hot spot in molecular biology research. In the research of cancer, RNAi has been broadly applied in inhibiting cancer anti-apoptosis gene, silencing oncogenes, cell cycle regulation, anti-angiogenesis, enhancing chemotherapy sensitivity and gene function studies.

关 键 词：RNA干扰 肿瘤 肿瘤相关基因 

分 类 号：R730.5[医药卫生—肿瘤]