牙源性角化囊肿的诊断和治疗  

Diagnosis and Treatment of Odontogenic Keratocyst

作　　者：罗光明[1] 李美琼[1] 杨湛 

机构地区：[1]昆明市第一人民医院口腔科,昆明650011 [2]云南省第三人民医院口腔外科,昆明650011

出　　处：《医学综述》2010年第1期98-100,共3页Medical Recapitulate

摘　　要：牙源性角化囊肿(OKCs)是一种好发于下颌角及升支部的发育性囊肿。与其他牙源性囊肿相比,OKCs中上皮细胞增殖活性较高、基因片断PTCH突变率高、有丝分裂计数升高,CK16、CK17、CK19等肿瘤标志物高表达。故而,认为OKCs是一良性囊性肿瘤。OKCs的诊断主要依靠影像学、病理学的检查。OKCs的治疗推荐外科的摘除术、周围骨切除术等侵袭性方法,但青年患者OKC病变涉及颌骨及牙的发育时,为了避免侵袭性方法的不良反应,袋形缝合术、减压或冲洗疗法等保守疗法在治疗OKCs中有诸多优点。Odontogcnic keratocyst（OKC） is a developmental odontogenic cyst most commonly occuring in the angle of the mandible and the ascending ramus. In contrast to other odontogenic cysts, OKCs have higher proliferative activity in epithelium, more frequent mutations of PTCH gene, higher mitotic count, overexpression of tumor makers such as CK16, CK17,and CK19. Thus,it is suggested the OKC might be a kind of benign cystic neoplasm rather than simple odontognnic cyst. The diagnosis of OKC is mainly depending on radiologic and pathologic characteristics. There arc two means for the treatment of OKC ：conservative or aggressive management. Aggressive methods including surgical enuclcation and peripheral ostectomy are recommended in the treatment of OKC However,for the young patients, conservative approaches such as marsupialization, decompression or douche treatments have some advantages because they can avoid some kinds of adverse effects produced by aggressive methods.

关 键 词：囊肿 牙源性角化囊肿 牙源性肿瘤 诊断 治疗 

分 类 号：R739.82[医药卫生—肿瘤]