硝酸布康唑的合成  

Synthesis of butoconazole nitrate

作　　者：张海波[1,2] 金荣庆[1,2] 王志贤[1,2] 

机构地区：[1]扬子江药业集团有限公司 [2]江苏(泰州)新药研究院,泰州225321

出　　处：《海峡药学》2009年第12期215-217,共3页Strait Pharmaceutical Journal

摘　　要：目的合成硝酸布康唑。方法以4-氯苄基氯为起始原料,经Grignard反应、缩合、氯化、缩合、成盐等5步反应制得目标化合物。结果目标化合物的熔点、红外光谱均与文献报道一致,总收率为37.9%,纯度为99.6%(HPLC法)。结论本工艺操作简单,成本较低,适合工业化生产。OBJECTIVE To synthesize butoconazole nitrate.METHODS The Target compound was synthesized from α,4-dichlorotoluene as a starting material via five steps including Grignard reaction,condensation,chlorination,condensation and salification.RESULTS The structure of the target compound was confirmer by melting point,IR analysis.The total yield of butoconazole nitrate was 37.9%,HPLC purity 99.6%.CONCLUSION This cost-saving and simplified method can be used in the industrial manufacture.

关 键 词：硝酸布康唑 抗真菌 合成 

分 类 号：R978.5[医药卫生—药品] R379.4[医药卫生—药学]