纳米钙磷结晶种植体表面理化性能分析  

Analysis of physiochemical properties of implant surface with nano-scale calcium phosphate crystal

作　　者：刘臣汉[1] 邓飞龙[1] 张佩芬[1] 刘森庆[1] 张华[1] 张辉[1] 罗智斌[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院.口腔医学研究所,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2009年第6期14-18,44,共6页Chinese Journal of Stomatological Research(Electronic Edition)

摘　　要：目的探讨两种纳米钙磷结晶种植体表面理化性能的差异。方法通过扫描电镜(SEM)观察两种种植体纳米晶体涂层表面形貌,能谱分析(EDS)、X射线光电子能谱仪(XPS)和X射线衍射(XRD)分析涂层晶体的化学组分及晶相,原子力显微镜(AFM)检测表面粗糙度,测量超纯水、二碘甲烷、甘油和甲酰胺在样品表面的接触角并计算表面能。结果BiconNanoTiteTM种植体表面可见直径20～200nm、圆形或椭圆形晶体随机分布并与表面融为一体;直径20～100nm粒状晶体散在分布于3INanoTiteTM种植体表面,在凹陷周围密集累积成白色山峰状,凹陷底部晶体数量较少,钛基体外露。XPS证实BiconNanoTiteTM种植体表面的纳米晶体化学组分为Ca10(PO4)6(OH)2和CaCO3,3INanoTiteTM种植体表面晶体化学组分是Ca8H2(PO4)6·5H2O。XRD显示两种种植体表面涂层晶体均为无定形结晶。BiconNanoTiteTM和3INanoTiteTM的表面粗糙度中,轮廓算术平均偏差(Ra)分别为(0.43±0.10)μm和(0.15±0.05)μm,微观不平度和点高度(Rz)分别为(2.13±0.7)μm和(0.64±0.03)μm,BiconNanoTiteTM的Ra和Rz均较3INanoTiteTM的高(P<0.05)。BiconNanoTiteTM和3INanoTiteTM的分散成分分别为24.49、24.10mN·m-1,极性成分分别为17.82、11.04mN·m-1,总表面能分别为42.30、35.15mN·m-1。结论BiconNanoTiteTM种植体表面纳米晶体的中含有Ca10(PO4)6(OH)2,在化学成份上较3INanoTiteTM的纳米晶体更接近羟磷灰石,物理化学性能较好。Objective To compare the physical and chemical properties of two kinds of implant surfaces with nano-scale calcium phosphate crystal. Methods The morphologies of two nano-crystal coatings on implant surface were observed by scanning electron microscopy （SEM）. The composition and crystal phase of the two coatings were analyzed by X-ray diffraction （XRD）, energy dispersive spectrometry （EDS） and X-ray photoelectron spectroscopy （XPS）. Surface roughness was detected by atomic force microscope （AFM）. Contact angles formed by four kinds of liquids on the surfaces of the two types of specimens were measured and the surface energy was calculated. Results The crystal diameters on Bicon NanoTiteTM surface ranged from 20 nm to 200 nm. Round and elliptic particles distributed stochastically and integrated with the surface. The irregular particles ranging from 20 nm to 100 nm in diameter were distributed dispersedly on the 3I NanoTite^TM implant surface. The amount of the crystal at the bottom of the depressed area was relatively low, the titanic substrate was exposed. XPS confirmed that the nano-crystals on Bicon NanoTite^TM implant surface were composed of Ca10（PO4）6 （OH）2 and CaCO3. The compositions of 3I NanoTite^TM implant surface was CasH2 （PO4）6·5H2O. The result of XRD showed that the crystals on the two implant surfaces were amorphous. The surface roughness of Bicon NanoTite^TM （Ra = 0.43 μm ± 0.10 μm, Rz = 2.13 μm ± 0.7 μm） appeared to be larger compared with 3I NanoTiteTM （Ra = 0.15 μm ± 0.05 μm, Rz = 0.64 μm ±0.03 μm） （P 〈 0.05）. Total surface energy in Bicon NanoTiteTM were higher than that of 3I NanoTite^TM. The dispersive component of Bicon NanoTite^TM and 3I NanoTiteTM were 24.49 mN·m^-1 and 24.10 mN·m^-1 respectively, the polar component were 17.82 mN ·m^-1 and 11.04 mN ·m^-1 respectively. Conclusions The nanocrystal on Bieon NanoTite^TM surface contains Ca10（PO4）6（OH）2, which is more close to hydroxyapatite in chemical structure and show

关 键 词：钛 牙种植体 钙磷 纳米颗粒 

分 类 号：R783.6[医药卫生—口腔医学]