兰索拉唑每日15mg与每日30mg治疗消化性溃疡的比较  

Lansoprazole 15 mg vs 30 mg daily in treatment of peptic ulcer

作　　者：姚健凤 顾同进 岑戎 

出　　处：《中国新药与临床杂志》1998年第5期279-280,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的：探索兰索拉唑１５ｍｇ／ｄ和３０ｍｇ／ｄ治疗消化性溃疡的比较。方法：６３例经胃镜证实为活动性消化性溃疡病人，随机分成１５ｍｇ／ｄ组３３例，３０ｍｇ／ｄ组３０例，疗程均为４ｗｋ。疗程结束后３ｄ内复查胃镜。结果：用药４ｗｋ胃镜下溃疡愈合率（疤痕期或溃疡消失）１５ｍｇ／ｄ组为８５％，３０ｍｇ／ｄ组为８７％。２组总有效率各为１００％（Ｐ＞０．０５）。服药后中上腹疼痛消失及反酸症状消失，１５ｍｇ／ｄ组与３０ｍｇ／ｄ组依次为５．９±ｓ１．８ｄ，４．５±１．８ｄ与３．２±１．４ｄ，３．０±１．０ｄ。２组差别均有非常显著意义（Ｐ＜０．０１）。结论：口服兰索拉唑１５ｍｇ／ｄ总有效率与口服３０ｍｇ／ｄ相仿。AIM: To compare lansoprazole 15 mg and 30 mg daily in the treatment of peptic ulcer. METHODS:63 patients with peptic ulcer were randomly divided into 2 groups: 33 patients in group A were treated with lansoprazole 15 mg/d,30 patiants in group B were treated with lansoprazole 30 mg/d. The therapeutic courses were all 4 wk. Within 3 d after the therapeutic course, all of the patients were reexamined with gastroscopy. RESULTS:After 4 wk of medication, 85% of the patients' ulcers in group A and 87% in group B were healed completely(ulcers scared or disappeared). The total effective rate was 100 % for each group (P>0.05). The symptom of mid epigastric pain of the patients in group A disappeared within 5.9±s 1.8 d since taking the drug, and in group B , the pain disappeared within 3.2 ± 1.4 d. And the symptom of acid regurgitation in group A disappeared within 4.5±1.8 d since taking the drug, and in group B , it disappeared in 3.0±1.0 d(P<0.01). CONCLUSION :Peptic ulcer without complication can be treated with lansoprazole 15 mg/d taken orally, its effect is as same as that of lansoprazole 30 mg/d orally, and the symptom of 30 mg/d disappeared more quickly than that of 15 mg/d.

关 键 词：兰索拉唑 消化性溃疡 胃镜检 用药计划 

分 类 号：R573.1[医药卫生—消化系统] R975.6[医药卫生—内科学]