卒中后抑郁Nogo-P300的执行功能分析  

Executive function of Nogo-P300 in patients with post-stroke depression

作　　者：杨庆南[1] 陈根荣[2] 郭琴[1] 张文新[2] 穆俊林[1] 姜文涛[1] 张宁[1] 

机构地区：[1]河南省精神病医院电生理室,河南新乡453002 [2]焦作煤业集团中央医院,河南焦作454000

出　　处：《新乡医学院学报》2009年第6期619-620,共2页Journal of Xinxiang Medical University

基　　金：河南省教育厅基金资助项目(编号:2008A310009)

摘　　要：目的通过事件相关电位检测,探讨卒中后抑郁患者的执行功能。方法对12例卒中后抑郁患者(观察组)及12例健康者(对照组)进行事件相关电位检测,受试者须对稀有声刺激执行按键反应(代表Go反应),对标准声刺激不执行按键反应(代表Nogo反应),通过头顶中央(Cz)记录大脑对听觉刺激信号产生的Nogo-P300波形,对Nogo-P300中的主成分Nogo-N2、Nogo-P3的波幅分别测量。结果观察组Nogo-N2、Nogo-P3波幅低于对照组,2组相比差别有统计学意义(P<0.01)。结论Nogo-N2、Nogo-P3显示反应抑制,可为卒中后抑郁提供执行功能的依据。Objective To investigate the execution function of patients with post-stroke depression by detecting event-related potential. Methods Event-related potential were detected in 12 post-stroke depression patients （observation group） and 12 healthy people（ control group） subjects were required to press the key when they experience a rare acoustic stimulus （ on behalf of Go response） , and were not required to press the key when they experience a standard acoustic stimulus （ on behalf of Nogo response）. Nogo-P300 waveform from brain which response to auditory stimulation signal were recorded by the recording electrode, and the amplitudes of Nogn-N2 and Nogo-P3 were measured. Results The amplitudes of Nogo-N2 and Nogo-P3 in observation group were significantly lower than those in control group （ P 〈 0.01 ）. Conclusion The Nogo-N2 and the Nogo-P3 can showed executive function of patients with post-stroke depression.

关 键 词：卒中后抑郁 Nogo-N2 Nogo-P3 反应抑制-执行功能 

分 类 号：R749.1[医药卫生—神经病学与精神病学]