以颞叶癫为主要表现的海马区胶质瘤的病理特点  

Hippocampus glioma with temporal lobe epilepsy as the main manifestation:the clinicopathologic properties

作　　者：马小梅[1] 刘惠敏[1] 李玉莉[1] 何金[1] 王良哲[1] 徐毅[1] 陈兵[1] 

机构地区：[1]第二军医大学长征医院病理科,上海200003

出　　处：《第二军医大学学报》2010年第1期60-62,共3页Academic Journal of Second Military Medical University

摘　　要：目的探讨引起颞叶癫(TLE)的海马区胶质瘤的病理特点。方法TLE伴海马区占位患者6例,男2例,女4例,术前最长癫发作病史4年。回顾性分析6例患者的临床病理资料。结果6例患者均行手术治疗,病理诊断均为胶质瘤,其中血管中心性胶质瘤(AG)1例,毛细胞星形细胞瘤(PA)1例,星形细胞瘤1例,少突-星形细胞瘤1例,少突胶质细胞瘤1例,胶质母细胞瘤1例。神经胶质原纤维酸性蛋白(GFAP)均呈强阳性。术后5例癫发作消失,1例复发并行二次手术。结论以TLE为主要表现的海马区胶质瘤病理学以低级别胶质瘤常见,分型广泛,手术效果良好。Objective To study the clinicopathologic properties of hippocampus glioma with temporal lobe epilepsy（ TLE） as the main manifestation. Methods The clinical data of 6 patients with TLE and hippocampus masses were retrospectively analyzed. The 6 patients included 2 males and 4 females,with the longest history of epilepsy being 4 years. Results All the 6 patients were surgically treated and were pathologically confirmed to have gliomas,including one angiocentric glioma（ AG） ,one pilocytic astrocytoma（ PA） with mucous degeneration,one astrocytoma,one oligoastrocytomao,one oligodendroglioma and one glioblastoma. Glial fibrillary acidic protein （ GFAP） was strongly positive in all cases. Epilepsy disappeared after surgery in 5 cases; one patient had recurrence and received a second operation. Conclusion Hippocampus gliomas with TLE as the main manifestation are usually low-grade gliomas of various types,and operation can obtain satisfactory prognosis.

关 键 词：癫痫 海马 胶质瘤 血管中心性生长 血管中心性胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤] R742.1[医药卫生—临床医学]