多基因变异对体外受精结局的影响  

Influence of multiple gene variation on IVF outcome

作　　者：姚瑶[1,2] 胡永芳[1] 

机构地区：[1]北京大学第三医院药剂科,北京100191 [2]北京大学药学院药事管理与临床药学系,北京100191

出　　处：《中国药理学通报》2010年第1期14-17,共4页Chinese Pharmacological Bulletin

基　　金："十一五"重大新药创制资助项目(No2008ZX09312-015)

摘　　要：外源性促性腺激素广泛应用于体外受精(in-vitro ferti-lization,IVF)促超排卵(controlled ovarian stimulation,COH),具有促进卵泡成熟和排卵的作用。除了年龄、卵巢储备等环境因素外,卵巢对这些激素的反应性还受到遗传因素的影响。该文将从遗传药理学角度阐述导致卵巢反应性个体差异的原因,综述FSHR和ESR等基因的遗传变异对促超排卵、体外受精结局的影响。Exogenous gonadotropins are widely used in controlled ovarian stimulation （COH） for patients undergoing in-vitro fertilization （IVF）,because of the effect of follicle maturation and ovulation. Except for environmental factors such as age and ovarian reserve,genetic variability seems also to be a key factor in determining the ovarian response to the exogenous gonadotropins. Inthis review,the reason for the interindividual difference in ovarian resoponse as well as the influence of the genetic polymorphisms of FSHR and ESR on COH and IVF outcome has been summarized.

关 键 词：促超排卵 体外受精 卵巢反应性 促卵泡激素受体基因 雌激素受体基因 单核苷酸多态性 

分 类 号：R-05[医药卫生] R321.1