FXYD3蛋白在胃腺癌中的表达及意义  

Expression and Significance of FXYD3 Protein in Gastric Adenocarcinoma

作　　者：朱振龙[1,2] 张钰[3] 杨艳红[1] 鞠晓静[1] 王政民[1] 崔冬生[2] 胡拥军[4] 王铭维[2] 孙晓峰[2,5] 

机构地区：[1]河北医科大学第一医院病理科,石家庄050031 [2]河北医科大学科研中心 [3]河北医科大学临床学院 [4]河北医科大学实验动物学部 [5]瑞典林雪平大学肿瘤学系

出　　处：《肿瘤防治研究》2010年第1期60-62,69,共4页Cancer Research on Prevention and Treatment

基　　金：河北省2006年科学技术研究与发展指导计划资助项目(062761285)

摘　　要：目的探讨FXYD3(Mat-8)蛋白在胃腺癌中的表达及其临床病理意义。方法采用免疫组织化学的方法检测29例正常胃黏膜和51例胃腺癌组织中FXYD3蛋白的表达。结果FXYD3蛋白在胃腺癌中的阳性表达率为66.67%(34/51),明显高于正常胃黏膜组织中的27.59%(8/29),两者比较差异有统计学意义(P<0.05)。FXYD3蛋白的表达与患者性别、年龄及肿瘤大小、大体形态、组织学分级和淋巴结转移情况均无相关性(P>0.05)。结论FXYD3蛋白在胃腺癌中的表达上调,可能只是胃腺癌发生阶段的一个早期事件,与肿瘤的浸润转移可能关系不大。Objective protein in gastric ad To investigate the expression and clinieopathological significance of FXYD3（Mat-8） noearcinoma. Methods SP immunohistochemieal method was to used to detect the expression of FXYD3 in paraffin-embedded sections from 29 cases of normal gastric mucous tissue and 51 cases of gastric adenocarcinoma. Results The positive expression rate of FXYD3 protein in gastric adenocareinoma was 66. 67%（34/51） ,which was higher than that 27. 59% （8/29） in normal gastric mucous tissue. The statistically difference was significant （P〈0. 05）. FXYD3 protein expression was not obviously correlated with patient＇s gender, age and tumor size, general types, histological classification as well as lymph node metastasis （P〉0. 05）. Conclusion Up-regulation of the FXYD3 protein expression may be an early event of genesis in gastric adenoeareinoma, and it may not be obviously correlated with invasion and metastasis of gastric adenocarcinoma.

关 键 词：FXYD3蛋白 胃腺癌 免疫组织化学 临床病理 

分 类 号：R735.2[医药卫生—肿瘤]