维吾尔族妇女宫颈癌组织中HSP90的表达及其与HPV16的相关性  

Expression of HSP90 and HPV16 in Cervical Cancer in Urghur Women

作　　者：郝治[1] 刘红梅[1] 海米提.阿布都力木 

机构地区：[1]新疆医科大学厚博学院机能教研室,乌鲁木齐830054 [2]新疆医科大学基础医学院组胚教研室,乌鲁木齐830054

出　　处：《肿瘤防治研究》2010年第1期74-76,80,共4页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目(30460046)

摘　　要：目的探讨维吾尔族和汉族妇女中宫颈炎和宫颈癌组织中HSP90蛋白的表达和HPV16型感染的情况。方法采用免疫组织化学SP法和聚合酶链反应(PCR)技术检测66例宫颈炎组织和92例宫颈癌组织中HSP90蛋白的表达和HPV16的感染情况。结果HSP90蛋白在维、汉宫颈癌组织中的阳性率高于维、汉宫颈炎组织(77.17%,56.06%)(P<0.05);HSP90蛋白的阳性率表达在维、汉宫颈癌组织间差异有统计学意义(P<0.05),并且汉族高于维吾尔族(83.33%,74.19%)。在HPV16型感染的宫颈癌组织中维吾尔族阳性率(58.06%)高于汉族(16.67%)(P<0.05)。HPV16型感染在宫颈癌组织中的阳性率高于宫颈炎组织(44.56%,12.12%)(P<0.05)。维、汉宫颈癌组织中HSP90的表达与HPV16型感染呈正相关性(r=0.361,P<0.05)。结论通过对HSP90蛋白和HPV16联合检测,可能作为检查宫颈癌的标志物,提高宫颈癌的检出率。Objective To investigate the expression of the HSP90 protein and HPV16 infection in cervicitis and cervical cancer tissues from Urghur and Han women. Methods The expression of HSP90 protein in 66 cervicitis tissues and 92 cervical cancer tissues was detected by using SP immunohistochemistry, and the infection status of HPVI6 in these tissues was studied by PCR using specific primer for HPV16. Results The overall expression rate of HSP90 in cervical cancer tissues （77. 17%） from both ethnic groups was higher than that in cervicitis tissues （56. 06%）from Urghur and Han women comhined（P〈0. 05）. The expression rate of HSP90 in the cervical cancer tissues from Han women was higher than that in Urghur women （83. 33% vs. 74. 19%） with the difference being significant （P〈0. 05）. The infection rate of HPV16 in cervical cancer tissues from Urghur women（58. 06%） was higher than that in Han women（16. 67%） （P〈0. 05）. The infection rate of HPV16 in cervical cancer tissues was higher than that in cervieitis tissues （44. 56% vs. 12. 12%） （P%0. 05）. The expression of HSP90 and the infection of HPV16 were correlated positively in cervical cancers of both ethnic groups （r= 0. 361, P〈0. 05）. Conclusion The detection of both HSP90 expression and HPV16 infection will improve the diagnosis rate of cervical cancer.

关 键 词：宫颈癌 乳头状瘤病毒 HSP90 维吾尔族 

分 类 号：R737.33[医药卫生—肿瘤]