轻度认知功能障碍的磁共振弥散张量成像研究  

A diffusion tensor magnetic resonance imaging for studying white matter changes in patients with mild cognitive impairment

作　　者：管锦群[1] 王鲁宁[1] 张熙[1] 蒋田仔[3] 安宁豫 王奇峰[3] 张军 

机构地区：[1]解放军总医院南楼神经内科,北京100853 [2]南楼放射科 [3]中国科学院自动化研究所 [4]北京军区门诊部

出　　处：《中华内科杂志》2010年第2期107-110,共4页Chinese Journal of Internal Medicine

基　　金：国家自然科学基金（60831004）;军队保健专项课题（07BJZ04）

摘　　要：目的应用磁共振弥散张量成像技术以及自动化影像分析工具研究遗忘型轻度认知功能障碍（aMCI）大脑白质结构的变化。方法对受试者进行临床和神经心理评估，31例受试者（aMCI组15例，对照组16例）接受磁共振弥散张量成像技术扫描。所有影像资料经与标准模板配准后，采用基于像素的图像分析法确定两组各向异性分数有差异的脑区。结果aMCI组简易智力状态检查量表（MMSE）（26．93±1．49）分，蒙特利尔认知评估量表（MoCA）（22．73±1．91）分，对照组MMSE（29．44±0．81）分，MOCA（26．50±1．17）分，差异有统计学意义（P〈0．05）。在aMCI组双侧额叶部分自质区域异性分数值低于对照组（P〈0．001）。结论额叶白质损伤可能参与了aMCI的病理生理过程的变化。Objectives To measure the microstructural differences in the brains of participants with amnestic mild cognitive impairment （aMCI） and compare with a control group using a magnetic resonance diffusion tensor imaging （DTI） technique with fully automated image analysis tools. Methods A standardized clinical and neuropsychological evaluation was conducted on each subject. 31 participants （15 participants with aMC1, 16 healthy elderly adults ） underwent magnetic resonance imaging （MRI）-based DTI. To control the effects of anatomical variation, the diffusion images of all participants were registered to standard anatomical space. Voxel-by-voxel comparisons showed significant regional reductions in white matter regions of fractional anisotropy （FA） in the participants with aMCI as compared with the controls. Results Significantly decreased FA value measurements （P 〈 0. 001 ） were observed in the right frontal white matter in participants with aMCI. Moreover, there was a statistically significant difference between the patients with aMCI and controls in considering the small regions of bilateral superior frontal gyrus white matter （P 〈 0. 001 ）. Conclusions White matter damage of frontal lobe may play an important role in histopathologic changes associated with amnestic mild cognitive impairment.

关 键 词：认知障碍 磁共振成像 弥散 痴呆 血管性 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]