T细胞性淋巴瘤组织CD56的检测及其与EB病毒的关系  

The detection of CD56 in T-cell lymphoma and its relationship with Epstein-Barr virus

作　　者：江庆萍[1] 周慕珩[1] 林汉良[1] 侯景辉[1] 

机构地区：[1]中山医科大学病理学教研室

出　　处：《中华病理学杂志》1998年第4期262-264,共3页Chinese Journal of Pathology

基　　金：国家自然科学基金

摘　　要：目的探讨Ｔ细胞性淋巴瘤（ＴＣＬ）中ＣＤ５６的表达情况及ＣＤ５６阳性表达同爱波斯坦－巴尔病毒（ＥｐｓｔｅｉｎＢａｒＶｉｒｕｓ，ＥＢＶ）感染的关系。方法对４６例ＴＣＬ进行ＣＤ５６的免疫组织化学ＬＳＡＢ法检测及ＥＢＥＲｓ的原位杂交检测。结果（１）４６例ＴＣＬ中８例ＣＤ５６阳性（１７．４％），其中鼻腔、咽部和口腔阳性率最高（５／１７例，２９．４％）。弥漫性大细胞型淋巴瘤ＣＤ５６阳性率最高（６／１６例，３７．５％）。（２）４６例ＴＣＬ中２４例ＥＢＥＲｓ阳性（５２．２％）。（３）８例ＣＤ５６阳性病例中，４例ＥＢＥＲｓ阳性。结论ＣＤ５６的表达同ＴＣＬ发生部位和类型有一定关系。Objective To investigate the expression of CD56 and the relationship between CD56 positive expression and EBV infection in Tcell lymphoma (TCL) in Guangdong province. Methods Immunohistochemistry was used to detect CD56 and in situ hybridization was used to detect EBER in 46 cases of TCL. Results (1) 17.4% (8/46) TCL were CD56 positive. According to the site of origin, the TCL originated from the nose, pharynx and oral cavity had the highest CD56 positive rate (5/17, 29.4%). Anyhow, according to the type pattern, the diffuse large cell lymphoma had the highest CD56 positive rate (6/16, 37.5%). (2) 52.2% (24/46) of the TCl were EBER positive. (3) 4/8 cases of the CD56 positive TCl expressed EBER. Conclusion The findings suggest that the expression of CD56 in TCL was possibly related to original sites and TCL subtypes. EBV infection was not related to CD56 positive TCL in this study. 

关 键 词：淋巴瘤 T细胞 疱疹病毒 4型 CD56 

分 类 号：R733.402[医药卫生—肿瘤]