从E-Cadherins在不同生长方式胃癌中的表达探讨闵锡钧分类  

Expression of E-Cadherins in different growth patterns of gastric car- cinoma

作　　者：蔡建春[1,2,3,4] 陈治平[1,2,3,4] 游枫红[1,2,3,4] 王瑞年 萧树东 施尧[1,2,3,4] 江绍基 

机构地区：[1]福建医科大学附属协和医院肿瘤科及临床肿瘤研究室 [2]上海第二医科大学仁济医院 [3]福州卫生检疫局 [4]上海第二医科大学病理教研室

出　　处：《中华消化杂志》1998年第4期201-203,共3页Chinese Journal of Digestion

摘　　要：目的研究同种亲和性钙离子依赖细胞粘附分子Ｅ－Ｃａｄｈｅｒｉｎｓ（Ｅ９和Ｕｖｏｍｏｒｕ－ｌｉｎ）在不同生长方式胃癌中的表达。方法应用免疫组织化学技术对４６例新鲜胃癌标本中的Ｅ－Ｃａｄｈｅｒｉｎｓ进行检测。结果Ｅ－Ｃａｄｈｅｒｉｎｓ在胃正常小凹上皮细胞、慢性胃炎小凹上皮细胞和肠化腺体上皮中呈均质性表达，然而在胃癌细胞中却出现异质性减少至消失的表达，这种表现在于闵锡钧分类的浸润型胃癌（２４／２４，１００％）和分化不良的胃癌（２６／３１，８４％），且在分散单个浸润的胃癌细胞明显缺乏这种粘附分子。结论Ｅ－Ｃａｄｈｅｒｉｎｓ的不同表达可能决定着胃癌的生长方式，它可以解释胃癌闵锡钧分类发病机理的一个方面。Objective To study the expression of homophilic cell adhesion molecules E-Cadherins (E9 and Uvomorulin) for elucidating the pathogenesis of molecular basis in Ming's classification of gastric carcinoma according to its growth pattern. Methods E-Cadherins were examined immunohistochemically in 46 cases of surgical specimens of gastric carcinomas. Results The E-Cadherins were expressed homogeneously both in normal foveolar epithelium, and in gastric epithelium, intestinal metaplastic glandular epithelium of chronic gastritis. In the latter, it was usually polarized along the apical border of glands. However, it displayed heterogeneously reduced or lost expression in gastric carcinoma, especially in Ming's infiltrative type of gastric carcinoma(24/24 , 100% ), and also in poorly differentiated adenocarcinoma (26/31 , 84 % ). The singly scattered neoplastic cells usually lacked the expression of adhesion molecules. Conclusion The results demonstrate that the expression of E-Cadherins is different types of gastric carcinoma according to its growth pattern, may form the molecular basis for the pathogenesis of Ming's classification of gastric carcinoma. [

关 键 词：钙粘附糖蛋白类 胃肿瘤/分类 

分 类 号：R735.202[医药卫生—肿瘤]