活血益气明目胶囊对视网膜变性性疾病的防治作用  

Effect of Huoxueyiqimingmu Capsule on Retinal Degenerative Diseases

作　　者：王延东[1] 唐细兰[1] 朱晓波[1] 唐仕波[1] 

机构地区：[1]中山大学中山眼科中心,广东广州510060

出　　处：《中药材》2009年第12期1874-1877,共4页Journal of Chinese Medicinal Materials

基　　金：广东省科技计划项目(社会发展计划)(2006B35601001)

摘　　要：目的:探讨活血益气明目胶囊对视网膜变性性疾病的防治作用。方法:SD大鼠60只,随机分为阴性对照组、光化学损伤模型组、活血益气明目胶囊组。视网膜变性动物模型采用光化学损伤模型,光照后分别给予等量生理盐水或活血益气明目胶囊灌胃,14 d后,观察视网膜电图的改变,检测视网膜组织中超氧化物歧化酶(SOD)的活性内丙二醛(MDA)的含量,并进行视网膜透视电子显微镜和光学显微镜的组织学观察。结果:治疗后14 d,活血益气明目胶囊对实验大鼠光化学损伤后ERG a波及b波振幅的降低均有提高作用,活血益气明目胶囊组动物视网膜中SOD的活性显著高于光化学损伤模型组(P<0.01),而MDA的含量则显著低于光化学损伤模型组(P<0.01);通过视网膜透视电子显微镜和光学显微镜的组织学观察显示,活血益气明目胶囊组动物的病理组织学损害较光化学损伤模型组明显减轻。结论:活血益气明目胶囊是一种治疗视网膜变性性疾病的有效中药复方制剂。Objective：To investigate therapeutic effects of Huoxueyiqimingmu capsule on retinal degenerative diseases.Methods： Sixty SD rats were randomly divided into three groups：negative control group,light damage model group,Huoxueyiqimingmu capsule group.The light damage model was used as retinal degenerative diseases animal model.Normal saline and Huoxueyiqimingmu capsule were respectively administrated after light damage.After 14 days post-treatment,the change of electroretinogram was observed,content of malondialdehyde（MDA） and activity of superoxide dismutase（SOD） in rats retina were determined,and histopathologic changes were observed with transmission electron microscopy and light microscopy.Results：After 14 days post-treatment,Huoxueyiqimingmu capsule had protective effects on fall of ERG a wave and b wave amplitude induced by light damage.The activity of SOD in Huoxueyiqimingmu capsule group was higher than that in light damage model group（P〈0.01）,while the content of MDA in Huoxueyiqimingmu capsule group was lower than that in light damage model group（P〈0.01）.The histopathologic injury of rat retina in Huoxueyiqimingmu capsule group was lighter than that in light damage model group by means of transmission electron microscopy and light microscopy. Conclusions：Huoxueyiqimingmu capsule is effective to treat retinal degenerative diseases.

关 键 词：活血益气明目胶囊 视网膜变性 光化学损伤 

分 类 号：R774.13[医药卫生—眼科] R289.5[医药卫生—临床医学]