血清CA_125、CA_(15～3)和SF联合测定在卵巢肿瘤诊断中的意义  

The Diagnostic Value of the Combined Assay of CA 125 , CA 15—3 and Serum Ferritin

作　　者：徐成伟[1] 张贵宇[2] 

机构地区：[1]山东医科大学附属第二医院 [2]山东医科大学附属第一医院

出　　处：《当代医师》1998年第11期5-6,共2页

摘　　要：对５１例卵巢良、恶性肿瘤和２８例对照者的血清进行癌抗原１２５（ＣＡ１２５），癌抗原１５—３（ＣＡ１５—３）和铁蛋白（ＳＦ）等指标检测。结果：⑴卵巢恶性肿瘤者血清三项指标均值全部高于对照者和卵巢良性肿瘤患者，差异有显著性（Ｐ＜００５～００１）；⑵Ⅲ、Ⅳ期卵巢癌各项指标阳性率高于Ⅰ、Ⅱ期患者（Ｐ＜００５～００１），上皮性癌患者各指标阳性率高于非上皮性癌患者（Ｐ＜００５）；⑶判断卵巢的良、恶性，单项指标以ＣＡ１２５的诊断性能最好；⑷多项指标联合以ＣＡ１２５＋ＣＡ１５—３＋ＳＦ中任意二项同时增高作为阳性标准诊断性能最好。The cancer antigen 125(CA 125 ),cancer antigen 15～3 (CA 15～3 ) and serum ferritin (SF) in 51 cases of ovarian neplasma (36 cases cancer,15 cases benign tumor) and 28 normal controls were determined by enzyme immunoassay.The results showed :⑴The average value tumor markers in ovarian cancer was obviously higer than that of benign tumor and healthy controls(P<0 05～0 01).⑵The positive of tumor markers in stage I and Ⅱ patients of ovarian cancer was markedly lower than that of in stage Ⅲ and Ⅳ(P<0 05～0 01).⑶In the markers,the diagnostic value of CA 125 for ovarian cancer was best.⑷Combined assaying any two of the CA 125 ,CA 15—3 and SF were superior to use any one marker for the diagnosis of ovarian cancer.

关 键 词：卵巢肿瘤 癌抗原125 癌抗原15-3 血清铁蛋白 

分 类 号：R737.310.4[医药卫生—肿瘤]