核小体定位研究进展  

ADVANCES IN NUCLEOSOME POSITIONING

作　　者：蔡禄[1] 赵秀娟[1,2] 

机构地区：[1]内蒙古科技大学生物工程与技术研究所,包头014010 [2]内蒙古大学物理科学与技术学院,呼和浩特010021

出　　处：《生物物理学报》2009年第6期385-395,共11页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(60761001)~~

摘　　要：核小体定位在诸如转录调控、DNA复制和修复等多种细胞过程中起着重要作用。基因组上核小体位置的确定涉及DNA、转录因子、组蛋白修饰酶和染色质重塑复合体之间的相互作用。核小体定位、组蛋白修饰、染色质重塑等问题已成为目前遗传学研究的热点——表观遗传学——的重要研究内容。文章从核小体定位基本概念、核小体定位与基因表达调控的关系、核小体定位实验研究和理论预测工作等几个方面总结了核小体定位的最新研究进展。The nucleosome positioning plays a central role in diverse cellalar processes such as transcription control, DNA replication and repair. The determination of nucleosome position on genome involve in interactions among DNA, transcription factors, histone modification enzymes, and chromatin remodeling complexes. The study on nucleosome positioning, histone modication and chromatin remodeling is an important research field in epigenetics. The basic idea of nucleosome positioning, the relation between nucleosome positioning and gene expression regulation, experimental and theoretical works on nucleosome positioning were reviewed in this paper.

关 键 词：核小体定位 基因表达 实验图谱 理论预测 

分 类 号：Q34[生物学—遗传学]