RunX3蛋白在胃癌中的表达及其临床病理学意义  

Expression of Runx3 protein and its cliniopathologic significance in gastric carcinoma

作　　者：兰建云[1,2] 成秀梅[3] 袁苏娟[1,2] 陈海涛[1,2] 

机构地区：[1]南通大学第四附属医院 [2]盐城市第一人民医院病理科,盐城224006 [3]盐城卫生职业技术学院基础部,盐城224006

出　　处：《临床与实验病理学杂志》2009年第6期594-597,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨新型抑癌基因Runx3蛋白表达与胃腺癌发生、发展、临床病理特征及患者预后之间的关系。方法用免疫组织化学SP法,检测63例胃腺癌组织、19例胃黏膜不典型增生组织及10例因胃良性病变行部分切除的正常胃黏膜组织中Runx3蛋白的表达。结果(1)Runx3蛋白在胃癌中阳性表达率为39.7%,明显低于胃黏膜不典型增生组织68.4%及正常胃黏膜组织90%,差异具有统计学意义(P<0.05)。(2)Runx3蛋白阳性表达与胃癌组织病理分级、浸润深度、淋巴结转移有关,而与患者的年龄、性别、大小及临床分期无关。(3)Runx3蛋白表达阳性者的生存率高于表达阴性者的生存率(P<0.05)。Runx3蛋白阳性者,术后生存时间长。结论Runx3蛋白对胃癌的发生发展起重要作用,是评估胃癌患者预后的一项重要指标。Purpose To investigate the relationship between the expression of Runx3 protein and pathogenesis,development,clinieopathological features and its prognostic significance in gastric adenocarcinoma.Methods Immunohistochemical SP method was used to detect the expression of Runx3 protein in 63 cases of gastric cancer,19 cases of atypical hyperplasia and 10 cases of normal gastric mucosa obtained from patients whose partial gastrotomy was performed for benign diseases.Results Compared with gastric atypical hyperplasia tissue（68.4%） and normal gastric mucosa（90%）,the positive rate of Runx3 protein in gastric cancer（39.7%） was significantly lower（P〈0.05）;the expression of Runx3 protein was related to tumor differentiation,invasive depth and lymphnode metastasis, but not to age,sex,tumor size and TNM stages;the survival rate of the patients with Runx3 protein expression was higher than that without Runx3 expression（P〈0.05）.Conclusion Runx3 protein may play an important role in the occurrence and development of gastric cancer,and it is an important marker in evaluating the prognosis of the patients.

关 键 词：胃肿瘤 RUNX3蛋白 免疫组织化学 预后 

分 类 号：R735.2[医药卫生—肿瘤]