伊托必利与氟西汀联用治疗功能性消化不良的疗效观察  

Itopride and Flnoxetine in Treatment of Functional Dyspepsia

作　　者：李英[1] 黄华[1] 李未华[1] 

机构地区：[1]昆明医学院第二附属医院消化内科,云南昆明650101

出　　处：《昆明医学院学报》2009年第12期52-55,共4页Journal of Kunming Medical College

摘　　要：目的评价伊托必利联用氟西汀治疗功能性消化不良(FD)的疗效.方法将80例FD患者随机分为2组.观察组50例,给予伊托必利50mg,3次/d,氟西汀20mg,1次/d;对照组40例,给予伊托必利50mg,3次/d.疗程均为4周,比较两组临床症状的变化.结果观察组与对照组用药4周后临床主要症状均明显缓解(P<0.01或0.05);除恶心、呕吐和上腹部疼痛外,其他症状消失率观察组均优于对照组.观察组治疗总有效率为90.0%,对照组为55.0%,两组相比,差异有显著性意义(P<0.01).两组患者均无严重不良反应.结论伊托必利与氟西汀联合使用,可提高治疗FD的疗效,安全性好,值得临床推广应用.Objective To study the effect of itopride and fluoxetine on functional dys-pepsia（FD）.Methods 80 patients were randomly divided into two groups.In the observation group（n = 40 ,patients were given 50 mg itopride（3 times a day） and 20 mg fluoxetine（once a day） while in the control group（n = 40） patients were given 50 mg cmsapride（3 times a day）,for 4 weeks.Clinical symptoms were compared between tge two groups.Results The main clinical symptoms in both groups were significantly relieved after 4-week treatment（P 0.05）.The other symptoms except nausea,vomiting and upper abdominal pain disappeared more completely in observation group than incontrol group.The total effective rates were 90.0% and 55.5% in observation group and control group ,respective1y.The difference between the two groups was significant（P 0.01）.There was no severe side effect in both groups.Conclusion Jointly using itopride and fluoxetine can improve the effect and safety of treating FD,and it is worth promoting the application in clinic.

关 键 词：功能性消化不良 伊托必利 氟西汀 观察组 对照组 联用治疗 临床症状 主要症状 患者 治疗后 

分 类 号：R57[医药卫生—消化系统]