消化道肿瘤患者血浆孤啡肽水平的变化  

Alterations of plasma levels of orphanin FQ in patients with digestive tract cancer

作　　者：马晓兵[1] 石湘芸[1] 费宇行[1] 吴醒身[1] 刘桂芳[1] 

机构地区：[1]解放军海军总医院干三科

出　　处：《华人消化杂志》1998年第11期982-983,共2页

摘　　要：目的观察消化道恶性肿瘤患者血浆孤啡肽ＯＦＱ含量的变化．方法消化道恶性肿瘤患者１５例，男１１例，女４例，年龄３４岁～８２岁，平均６０岁．其中胃癌６例、结肠癌５例、食管癌４例．应用特异性放射免疫分析法测定其血浆含量．结果血浆ＯＦＱ水平（ｎｇ／Ｌ）在消化道肿瘤组为６６±１０，对照组为９±１，两者相比，Ｐ＜００１；血浆ＯＦＱ水平在胃癌、结肠癌和食管癌分别为７４±１６，９５±９和２０±４，前两者分别与后者相比，Ｐ＜００５；随着临床分期的进展，血浆ＯＦＱ水平升高越明显．结论血浆ＯＦＱ浓度可能参与肿瘤的病理生理过程；胃肠癌血浆ＯＦＱ水平显著高于食管癌；AIM To study the changes of orphanin FQ levels in plasma in patients with digestive tract cancer. METHODS The plasma levels of orphanin FQ were measured by using specific radioimmunoassay in 15 patients with digestive tract cancer and 19 healthy individuals. RESULTS The plasma level of orphanin FQ of cancers was 61ng/L ± 6ng/L and in normal controls 9ng/L ± 1ng/L ( P <0 01). The levels of orphanin FQ in plasma were 74ng/L ± 16ng/L , 95ng/L ± 9ng/L and 20ng/L ± 4ng/L in the carcinoma of stomach, the carcinoma of colon and the carcinoma of esophagus respectively. The difference was statistically significant ( P <0 05) between the carcinoma of stomach and carcinoma of esophagus and the carcinoma of colon and carcinoma of esophagus. With the progress of clinical stage, the level orphanin FQ was elevated obviously. CONCLUSION The elevated level of orphanin FQ in plasma is correlated with pathophysiological course of cancers. It was obviously higher in the gastrointestinal cancers than in the esophageal cancer. The elevated level of orphanin FQ might be one of the indicators for judging the degree of patient's condition.

关 键 词：消化系统肿瘤 孤啡肽 血液 胃肿瘤 结肠肿瘤 

分 类 号：R735.02[医药卫生—肿瘤]