新疆维吾尔族人寻常型银屑病与HLA-Cw*0602等位基因的关联研究  

Study on association of psoriasis vulgar in Uighurs from Xinjiang* with HLA-Cw*0602 allele

作　　者：朱明明[1,2] 普雄明[1,2] 吴卫东[1,2] 

机构地区：[1]石河子大学医学院,新疆石河子8320022 [2]新疆维吾尔自治区人民医院皮肤性病科,新疆乌鲁木齐830001

出　　处：《现代生物医学进展》2009年第22期4216-4218,4275,共4页Progress in Modern Biomedicine

基　　金：国家自然基金项目资助(30640056)

摘　　要：目的:寻找新疆维吾尔族人银屑病与HLA-Cw*0602等位基因的相关性。方法:运用聚合酶链反应-序列特异性引物(PCR-SSP)法,检测新疆维吾尔族人200例寻常型银屑病患者和200例健康对照的HLA-Cw*0602等位基因频率,分析携带该基因的银屑病患者与其家族史的相互关系。结果:①病例组HLA-Cw*0602等位基因频率较对照组显著升高(73%vs24%,X2=108.551,OR=10.171,95%可信区间6.410～16.140,P=0.000),且无性别差异;②携带HLA-Cw*0602等位基因的银屑病患者发病年龄早于不具有该等位基因的患者(80.2%vs28.6%,X2=10.256,OR=0.950,95%可信区间0.920～0.981,P=0.001);③有银屑病家族史患者携带HLA-Cw*0602等位基因的频率与无银屑病家族史的患者无显著意义(X2=0.000,OR=0.986,95%可信区间0.252～3.860,P=1.000)。结论:新疆维吾尔族银屑病患者与HLA-Cw*0602等位基因高度关联,且携带该等位基因的银屑病患者易发生早发型(发病年龄≤40岁)银屑病,但不能确定有家族倾向性。Objective：To investigate the relationship of HLA-Cw＊0602 allele and genetic susceptibility to psoriasis vulgar （PV） in Uighurs from Xinjiang. Methods： High-resolution polymerase chain reaction amplification with sequence specific primers（PCR-SSP） were used to detect the distribution frequencies of HLA-Cw＊0602 allele in 200 patients with PV and 200 healthy controls from Xinjiang Uighurs. The correlation of patients with PV and their family history was analyzed. Result： ① HLA-Cw＊0602 allelic frequency increased in patients with PV compared with control group （72%vs24%,X2=108.551,OR=10.171 ,95% confidential interval 6.410～16.140, P=0. 000）, and there was no difference between male and female patients with PV. ② The age at onset for Cw6 psoriasis was earlier than those for Cw6 negative ones（80.2%vs28.6%, X2=10.256,OR=0.950, 95% confidential interval 0.920～0.981, P=0.001）.③The frequency of HLA-Cw＊0602 allele was no difference in PV patients with positive history and that with negative one （X2=0.000,OR=0.986, 95% confidential interval 0.252～3.860,P=1.000）. Conclusion： There is relationship between HLA-Cw＊0602 allele and PV in the Uighurs from Xinjiang. The carriers of HLA-Cw＊0602 allele are easy to catch early-onset psoriasis （ages at onset less than 40 years）, but there is not relationship between them and their familial history.

关 键 词：寻常型银屑病 人类白细胞抗原 聚合酶链反应-序列特异性引物 等位基因 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]