S100A11的表达及其与胃癌的关系  

Expression and Significance of S100A11 in Gastric Carcinoma

作　　者：王妍[1] 贺修胜[1] 董娟慧[1] 陈苏琼[1] 李丽[1] 李春成[1] 姚旭炯[1] 

机构地区：[1]南华大学肿瘤所,湖南衡阳421001

出　　处：《现代生物医学进展》2009年第22期4303-4305,4335,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨S100A11在胃癌和正常胃粘膜组织中的表达及意义。方法:采用RT-PCR和Western Blot技术检测21对配对胃癌组织和正常胃粘膜组织中S100A11的表达情况。结果:胃癌组织S100A11 mRNA的表达量(1.26±0.03)高于正常胃癌粘膜组织中的表达量(0.75±0.04),两组比较差异有统计学意义(p<0.05)。S100A11蛋白在胃癌组织中的表达量(0.94±0.05)明显高于在正常胃粘膜组织中的表达量(0.39±0.05),两组比较差异有统计学意义(p<0.05)。结论:S100A11在胃癌组织中的表达量明显高于正常组织,提示其与胃癌的发生和发展有关。Objective：To investigate the expression and significance of S100A11 in human gastric carcinoma and surrounding normal tissue. Methods： The expression of S100A11 in 21 matched-pairs of gastric carcinoma tissues were detected by RT-PCR and Western blot methods. Results： The relative expression value of S100A11 mRNA found in human gastric carcinoma specimens was 1.26±0.03, and that did in surrounding normal tissue specimens was 0.75±0.04（p〈0.05）. The integral optical density value of S100A11 protein confirmed in human gastric carcinoma specimens was 0.94 ±0.05 and that did in surrounding normal tissue specimens was 0.39±0.05 （p〈0.05）. RT-PCR and Western blot indicated expression of S100A11 in gastric carcinoma was significantly higher than that in corresponding normal stomach tissue respectively. Conclusion： The expression of S100A11 was significantly higher in gastric cancer than in control normal tissue, which suggests that S100A11 plays a role in the tumorigenesis and development of gastric carcinoma.

关 键 词：胃癌 S100A11 WESTERN BLOT RT-PCR 

分 类 号：R735.2[医药卫生—肿瘤]