microRNAs调节肿瘤细胞转移表型的分子机制  

Molecular mechanism of effects of microRNAs on tumor cells metastasis

作　　者：罗恒[1] 玄香兰[1] 陈晓峰[1] 王和勇[1,2] 

机构地区：[1]同济大学附属上海市肺科医院,上海200433 [2]同济大学医学院肿瘤研究所,上海200433

出　　处：《现代生物医学进展》2009年第22期4359-4361,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30800631;30872553)资助;上海市科委科技支撑计划医学引导项目(0941196480)资助

摘　　要：microRNAs(miRNAs)是一类在转录后水平调控基因表达的内源性非编码小RNA分子。miRNAs具有癌基因与抑癌基因的功能,参与肿瘤细胞的增殖、粘附、侵袭、转移和肿瘤血管形成等过程。miRNAs可调节肿瘤细胞转移表型,主要通过改变肿瘤细胞黏附力、侵袭力与迁移力。本文重点介绍调节肿瘤细胞转移表型相关miRNAs及其作用的分子机制,以便为肿瘤转移的研究提供新思路。MicroRNAs （miRNAs） are endogenous, short noncoding RNA molecules that can regulate the gene expression in the post-transcriptional level. miRNAs have the function of both oncogenes or tumor suppress genes in the tumorigenesis. They play impotant roles in biological processes, such as proliferation, adhesion, invasion and metastasis of tumor cells and tumor angiogenesis. miRNAs have effect on metastasis phenotype by changing the adhesion, invasion and migration of tumor cells. This article provides an overview on miRNAs and its molecular mechanism to offer new idea on tumor metastasis.

关 键 词：MICRORNAS 肿瘤细胞 转移表型 侵袭转移 

分 类 号：R730.231[医药卫生—肿瘤]