中性内肽酶的肿瘤抑制作用  

Roles of Neutral Endopeptidase in Tumor Suppression

作　　者：王云超[1] 吴宏日[1] 蔡其燕[2] 

机构地区：[1]第三军医大学学员旅二队,重庆400038 [2]第三军医大学组织学与胚胎学教研室,重庆400038

出　　处：《现代生物医学进展》2009年第22期4390-4394,共5页Progress in Modern Biomedicine

摘　　要：中性内肽酶(NEP)是一种膜整合的神经肽降解酶,表达于机体多种组织细胞中,它能通过水解多种神经肽发挥广泛的生物学效应。NEP在前列腺癌细胞的表达可抑制肿瘤细胞的迁移、存活以及血管的生成。NEP的抗肿瘤作用机制包括:抑制cSrc介导的FAK活性、抑制PI3K介导的FAK磷酸化、抑制ERM与CD44的相互作用、抑制神经肽介导的Akt活性、与PTEN作用抑制Akt磷酸化以及下调促血管生成因子FGF-2。因此,对NEP肿瘤抑制功能的进一步研究可为肿瘤的治疗提供新的策略。Neutral endopeptidase （NEP） is a integral membrane neuropeptide degrading peptidase. NEP is normally expressed on a variety of tissue cells and can produce extensive biological effects by hydrolyse multiple neuropeptides. Expression of NEP in the prostate cancer cells can inhibit the cell migration, cell survival, and angiogenesis. The mechanisms of NEP＇s anti-tumor effects are including： inhibiting cSrc-mediated FAK activation, inhibiting PI3K-mediated FAK phosphorylation, inhibiting the interaction of ERM proteins with CD44, preventing neuropeptide-mediated activation of Akt, associating with PTEN to suppress Akt phosphorylation, and reducing angiogenic growth factor FGF-2. Thus, the further study on NEP＇s anti-tumor effects may provide a novel strategy for tumor therapy.

关 键 词：NEP 细胞迁移 细胞存活 血管生成 肿瘤抑制 

分 类 号：R730.23[医药卫生—肿瘤]