坎离颗粒对慢性心力衰竭大鼠骨骼肌乳酸与葡萄糖水平及Ca^(2+)-ATP酶活性的影响  

Effects of"Kanli Granule"on Lactic Acid,Glucose and Ca^(2+)-ATPase Activity in Skeletal Muscles of Rats of Chronic Heart Failure

作　　者：姚成增[1] 蒋梅先[1] 

机构地区：[1]上海中医药大学附属曙光医院心内科,上海200021

出　　处：《上海中医药大学学报》2010年第1期50-52,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30701135)

摘　　要：目的:观察坎离颗粒对慢性心力衰竭大鼠骨骼肌乳酸、葡萄糖水平及Ca^(2+)-ATP酶活性的影响。方法:以腹主动脉缩窄法复制慢性心力衰竭大鼠模型。32只大鼠随机分为假手术组、模型组、开搏通组、坎离颗粒组,每组8只。予相应的药物干预32周,观察各组大鼠骨骼肌组织乳酸、葡萄糖水平及Ca^(2+)-ATP酶活性变化。结果:慢性心力衰竭大鼠骨骼肌组织Ca^(2+)-ATP酶活性和葡萄糖水平降低,乳酸水平升高(P<0.05,P<0.01);中西药物均能不同程度地改善上述病理状况,但坎离颗粒在改善骨骼肌葡萄糖水平方面优于开搏通(P<0.01)。结论:坎离颗粒能改善慢性心力衰竭大鼠骨骼肌组织的糖代谢。Objective：To investigate the effects of ＂Kanli Granule＂ on lactic acid, glucose and Ca^2＋ -ATPase activity in skeletal muscles of rats of chronic heart failure（CHF）. Methods ： Chronic heart failure was established in rats by coarctating abdomi-nal aorta. Thirty-two rats were divided into four groups： sham group, model group, control group by captopril and treatment group by ＂Kanli Granule＂. Thirty-two weeks later, the lactic acid, glucose and Ca2＋ -ATPase activity in skeletal muscles of rats were detected. Reuslts ： In model group, the glucose and Ca2＋ -ATPase activity decreased and lactic acid increased （ P 〈 0. 05, P 〈0.01 ）; both ＂ Kanli Granule＂ and captopril could regulate the lactic acid, glucose and Ca2＋ -ATPase activity（ P 〈 0.05,P〈0.01）, but ＂Kanli Granule＂ had better effect than captopril in improving glucose（P〈0.01）. Conclusion： ＂Kanli Granule＂ is effective to improve glucose metabolism in skeletal muscles of rats of chronic heart failure.

关 键 词：慢性心力衰竭 坎离颗粒 乳酸 葡萄糖 CA^2+-ATP酶 大鼠 

分 类 号：R285.5[医药卫生—中药学] R541.4[医药卫生—中医学]