FAS蛋白表达与卵巢癌细胞凋亡的相关性研究  

The study of Relationship between Expression of FAS Protein and Apoptosis of Ovary Carcinoma

作　　者：娄阁[1] 钱素娟[2] 马玉彦[1] 周令望[2] 宁晓明[1] 

机构地区：[1]哈尔滨医科大学第三临床医学院,哈尔滨150040 [2]哈尔滨医科大学克山病研究所,哈尔滨150040

出　　处：《中国肿瘤》1998年第11期20-21,共2页China Cancer

基　　金：黑龙江省教委课题

摘　　要：[目的]探讨FAS基因与卵巢癌细胞凋亡的关系。[方法]应用免疫级化技术检测FAS蛋白，应用原位末端标记法（TUNEL）检测卵巢癌细胞凋亡。[结果]卵巢癌组织FAS蛋白阳性率为45．45％，细胞凋亡阳性率为75．00％。表达FAS蛋白的细胞与凋亡细胞分布区域基本一致。[结论]FAS基因通过调控细胞凋亡而参与卵巢癌的发生与发展。[Purpose]To study relationship betweem FAS gene and ovary carcinoma.[Methods]The FAS protein was detected by immunohistochemistry and the apoptosis of ovary carcinoma was detected by tagging unselected N-end-labeled.[Results]The positive rate of FAS protein was 45.45% and the positive rate of apoptosis was 75.00% in the tissue of ovary carcinomas.The distribution area of cells of expression of FAS protein and of FAS protein and of cells of apoptosis was consistent essentially. [Conclusion]FAS gene participated in the occurring and developing of ovary carcinomas by apoptosis controlled.

关 键 词：卵巢肿瘤 细胞凋亡 FAS基因 病理 

分 类 号：R737.310.2[医药卫生—肿瘤]