脂蛋白脂酶基因Ser447stop多态性与脑出血的关系  

Association of lipoprotein lipase Ser447stop gene polymorphisms with cerebral hemorrhage

作　　者：林慧琼[1] 李吕力[1] 刘晓春[2] 钟维章[1] 滕晓茗[1] 罗永坚[1] 张德敏[1] 

机构地区：[1]广西壮族自治区人民医院神经内科,广西南宁530021 [2]广西壮族自治区人民医院检验科,广西南宁2530021

出　　处：《中风与神经疾病杂志》2010年第1期23-25,共3页Journal of Apoplexy and Nervous Diseases

基　　金：广西科学基金项目(桂科青0229021)

摘　　要：目的探讨脑出血与脂蛋白脂酶基因Ser447stop多态性相关性。方法采用聚合酶链反应和限制性片段长度多态性方法(PCR-RFLP法)来检测脂蛋白脂酶基因Ser447stop多态性,其中对照者66例,脑出血患者69例,测定所有样本的血脂水平。结果1、脑出血患者组CG基因型和G等位基因频率显著低于对照组(P<0.05);2、脑出血患者组血清TG、LDL-c水平较对照组高(P<0.01);同时CHO、ApoAⅠ、ApoB水平降低(P<0.01);3、CC基因型LDL-c含量较CG型高(P<0.05)。结论脂蛋白脂酶基因Ser447stop多态性与脑出血有一定关联,G等位基因可能是脑出血的一种保护性因素。Objective To study the association of lipoprotein lipase Ser447stop gene polymorphisms with cerebral hemorrhage. Methods Use a PCR-RFLP to detect 135 subjects lipoprotein lipase Ser447stop genotypes （including 66 controls and 69 cerebral hemorrhage patients）. All the subjects＇ serum lipids and apolipoproteins levels were detected. Results The cerebral hemorrhage group carried less CG genotype and G allele than the control group. The cerebral hemorrhage group had higher TG and LDL-c levels than the eontrol group （P 〈 0.01 ） ;and the cerebral hemorrhage group had lower CHO,Apo A Ⅰ and ApoB levels than the control group（P 〈 0.01 ）. The CC genotype had higher LDL-c level than CG genotype. Conclusions The lipoprotein lipase Ser447stop G allele is correlated with cerebral hemorrhage and the Ser447 stop polymorphism of the LPL gene may be a protective factor against the development of cerebral hemorrhage.

关 键 词：脑出血 脂蛋白脂酶基因 Ser447stop位点 限制性片段长度多态性 

分 类 号：R743.34[医药卫生—神经病学与精神病学]