丁基苯酞治疗血管性痴呆的临床疗效观察  

Butylphthalide in the treatment of vascular dementia

作　　者：胡云南[1] 

机构地区：[1]福建省龙岩市第一医院神经内科,福建龙岩364000

出　　处：《中风与神经疾病杂志》2010年第1期26-27,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨丁基苯酞对血管性痴呆(VD)疗效和作用机制。方法96例VD患者随机分成丁基苯酞治疗组和胞二磷胆碱注射液对照组,分别在治疗10、21d进行简易精神状态评分(MMSE)和长谷川评分(IDS),同时测定与记忆有关的乙酰胆碱酯酶(AchE)的活性。结果丁基苯酞治疗组患者21d的MMSE和IDS评分均高于治疗前和一般治疗组(P<0.01),且丁基苯酞治疗组VD患者的乙酰胆碱酯酶(AchE)活性降低和血浆乙酰胆(Ach)含量升高(P<O.05)。结论丁基苯酞治疗VD疗效肯定,其机制可能与胆碱能神经系统功能增强有关。Objective To explore the effect and therapeutic mechanism of butylphthalide in treating vascular dementia（VD）. Methods The score of MMSE, HDS and the activity of cholinergic system in 96 patients with VD were detected and compared with control group in 10d and 21d respectively. Results The scores of MMSE and HDS of butylphthalide group were significantly higher than those of control group. Butylphthalide could decrease the activity of cholinesterase and improve content of acetylcholine in plasm on 21d. Conclusion Butylphthalide has definite effect on VD, which may improve the function of cholinergic system.

关 键 词：丁基苯酞 血管性痴呆 胆碱能神经系统 

分 类 号：R749.13[医药卫生—神经病学与精神病学]