垂体腺瘤中Ki-67、E-Cad、nm23的蛋白表达及临床意义  

Expression and clinical significance of Ki-67,E-Cad and nm23 in human invasive pituitary adenomas

作　　者：罗志谋[1] 袁春艳[1] 谢蕴[1] 潘玉林[1] 浦文兰[1] 蔡沛然[1] 

机构地区：[1]上海瑞金医院集团闵行中心医院病理科,上海201100

出　　处：《蚌埠医学院学报》2010年第1期52-54,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨垂体腺瘤细胞中Ki-67、E-Cad及nm23的蛋白表达与腺瘤体积、激素分泌及侵袭性的临床意义。方法:应用免疫组织化学二步法同时检测3种蛋白在52例垂体腺瘤中的表达水平。结果:Ki-67蛋白阳性表达在垂体腺瘤的侵袭性组与非分泌型组中与非侵袭性组及分泌型腺瘤组差异均无统计学意义,与肿瘤体积大小无明显关系(P>0.05);E-Cad蛋白在侵袭性和非分泌型腺瘤中表达均低于非侵袭性与分泌型腺瘤组(P<0.05),但与肿瘤体积大小均无明显关系(P>0.05);nm23基因蛋白在侵袭性腺瘤中的阳性表达低于非侵袭性腺瘤组(P<0.05),但与激素分型及肿瘤体积大小均无明显关系(P>0.05)。结论:Ki-67蛋白阳性高表达及E-Cad、nm23蛋白低表达,与垂体腺瘤的侵袭性相关,并影响腺瘤细胞的分化,促进细胞的增殖活性增强。可以作为临床评估垂体腺瘤侵袭能力与预后判断的生物学指标之一。Objective：To study the association of the expression of Ki-67,E-Cad and nm23 with the volume,hormone secretion and invasion of pituitary adenomas.Methods：The expression of Ki-67,E-Cad and nm23 in 52 cases of pituitary adenomas was examined by immunohistochemical methods.Results：The expression level of Ki-67 in the invasive and nonsecretive pituitary adenomas was significantly higher than that in the noninvasive and secretive ones,and the expression level of Ki-67 was not related to the volumes of pituitary adenomas（P〉0.05）.The expression level of E-Cad in the invasive and unsecretive pituitary adenomas was significantly lower than that in the noninvasive and secretive ones（P〈0.05）,and the expression level of E-Cad was negatively correlated with the volumes of pituitary adenomas（P〉0.05）.The expression level of nm23 in the invasive pituitary adenomas was significantly lower than that in the noninvasive ones（P〈0.05）,and was not related to the hormone typing and volume of the tumor（P〉0.05）.Conclusions：High expression of Ki-67 and low expression of E-cad and nm23 are positively related to the invasiveness of pituitary adenomas,and may affect the cell differentiation and promote proliferation of the cells in pituitary adenomas.Thus,the expression of Ki-67,E-Cad and nm23 could be used to evaluate the invasion and prognosis of pituitary adenoma.

关 键 词：垂体腺瘤 KI-67 E-钙黏蛋白 NM23基因蛋白 免疫组织化学 

分 类 号：R736.4[医药卫生—肿瘤]