库普弗细胞在酒精性肝病发病机制中的作用研究进展  

Research development of the role of Kupffer cell in the pathogenesis of alcoholic liver disease

作　　者：代雪飞[1] 吕雄文[1] 李俊[1] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032

出　　处：《安徽医药》2010年第1期1-4,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省自然科学基金项目(No070413078);安徽省高等学校省级自然科学研究重点项目(NoKJ2008A048)

摘　　要：酒精性肝病(alcoholic liver disease,ALD)是由于酒精的过量摄入导致的肝脏损害及其一系列病变,给人类健康带来极大的威胁,是我国目前面临的一大医学问题。库普弗细胞(kupffer cell,KC)是一种肝巨噬细胞,在ALD过程中能够在内毒素(LPS)、氧自由基等刺激下产生一些列细胞因子和炎症介质,介导肝细胞炎症反应,导致肝脏损伤。本文综述了国内外对于KC在ALD发病机制中的作用研究进展。Alcoholic liver disease is a kind of liver damage caused by a series of lesions due to excessive intake of alcohol, which is a great threat to human health and is also a major medical problem our country is facing currently. Kupffer cells is a kind of liver macrophages, in the ALD process ,it can be stimulated by endotoxin（LPS） and oxygen free radicals, then it release a series of cytokines and inflammatory mediators, causing inflammatory response in liver cells,leading to liver damage. In this paper, there are some researches both at home and abroad for the role of Kupffer cell in the pathogenesis of alcoholic liver disease.

关 键 词：酒精性肝病 库普弗细胞 内毒素 氧自由基 细胞因子 

分 类 号：R575[医药卫生—消化系统] R363.14[医药卫生—内科学]