丁苯肽胶囊对脑梗死患者血清MMP-9及TIMP-1的影响  

Influence of dl-3-budylphthalinde on the Serum Levels of MMP-9 and RIMP-1 in Patients with Acute Cerebral Infarction

作　　者：刘明伟[1] 陆爽[1] 郝丽[1] 林昕[1] 杨利荣[2] 曲艳[1] 张明谦[1] 

机构地区：[1]云南省昆明市延安医院急诊科,650051 [2]云南省第一人民医院EICU

出　　处：《中华全科医学》2010年第2期183-184,共2页Chinese Journal of General Practice

摘　　要：目的探讨dl-3-正丁基苯酞软胶囊对急性脑梗死患者血清基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制剂-1(TIMP-1)的影响并研究其作用机制。方法将40例急性脑梗死患者随机分成两组,A组(银杏达莫20ml,1次/d,连续14d,静脉点滴);B组使用dl-3-正丁基苯酞软胶囊每次口服200mg,3次/d,疗程为24d。同期选择非脑血管病患者20例作为对照组。检测治疗前和治疗后第7天患者血清MMP-9及TIMP-1浓度的变化,测定治疗前、治疗第30天的NIHSS评分,判定两组的疗效。结果在治疗第7天,B组的MMP-9浓度明显低于A组(P<0.01)。治疗第7天时,与A组相比,B组TIMP-1浓度升高明显(P<0.01)。B组治疗的有效率及显效率明显高于A组(P<0.05)。结论dl-3-正丁基苯酞软胶囊能够直接降低血清MMP-9的浓度,或通过调节TIMP-1来降低MMP-9水平,可能是其有效治疗急性脑梗死的机制之一。Objective To study the influence of dl-3-budylphthalinde on the serum levels of MMP-9 and TIMP-1 in patients with acute cerebral infarction.Methods 40 patients with acute cerebral infarction were randomly divided into routine group（20 cases） and dl-3-budylphthalinde group（20 cases）.All cases were given routine treatment.The dl-3-budylphthalinde group were added with dl-3-budylphthalinde 200mg,twice a day,totally 24 d.The serum levels of MMP-9 and TIMP-1 were investigated before and 24 d after treatment,and the NIH scale and clinical outcome were evaluated before and 30d after treatment.Results The therapeutic efficacy of dl-3-budylphthalinde group was significantly better than that of routine group（P0.05）.The serum levels of MMP-9 of the dl-3-budylphthalinde group was lower than that of routine group after 24 d（P0.01）.Compared with routine group,the serum levels of TIMP-1 of the dl-3-budylphthalinde group was higher after 24 d（P0.01）.Conclusion Our research indicated that dl-3-budylphthalinde can reduce the injury of ischemic brain cells and improve therapeutic efficacy probably through down regulation of serum MMP-9 level or through upregulating TIMP-1 expression to reduce MMP-9 level.

关 键 词：dl-3-正丁基苯酞 急性脑梗死 基质金属蛋白酶-9 基质金属蛋白酶抑制剂-1 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R972[医药卫生—临床医学]