瘢痕疙瘩发病机理的研究概况  

Research Progress of Pathogenesis of Keloids

作　　者：陈丹丹[1] 黄关宏[1] 王忠明[1] 

机构地区：[1]安徽蚌埠医学院

出　　处：《中华全科医学》2010年第2期229-230,共2页Chinese Journal of General Practice

摘　　要：瘢痕疙瘩有着过度生长,侵犯邻近组织,手术切除后极易复发,治疗效果不佳等特点,成为当今医学界面临的一个重大难题。它常在易感人群外伤后发生。由于发病机制十分复杂,其形成机制迄今尚未完全阐明,目前所知与外伤,烧伤,手术,感染,异物,机体局部胶原代谢失调,遗传及局部免疫功能等多种因素有关。本文就其在遗传背景、免疫作用、细胞因子、成纤维细胞等方面的研究进展进行综述,这不仅有利于瘢痕疙瘩的临床诊断和治疗,而且有助于对创伤愈合机理产生新的认识。以期为进一步研究和治疗提供一些启示。Keloids is a severe problem in medicine because of the traits of overgrowth,impinging the normal tissue,easy to recur after removed and bad curative effect.It always occur in susceptible population because of external injury,The pathogeny of kelods is still unclear so far.At present it was related with multiple factors,such as：external injury,burn,operation,infection,foreignbody,local collagen metabolism disorder,heredity and local immune function and so on.This article will report and analyze the research advances in genetics immunifaction,cytokine and fibroblasts of keloids in order to provide some enlightenment for their therapy and further research.This may not only result in better diagnosis and treatment options for keloid,but also provide new insights into the complex mechanisms of would healing,in order to provide some enlightenment for their therapy and further research.

关 键 词：瘢痕疙瘩 遗传学 免疫 细胞因子 成纤维细胞 

分 类 号：R619.6[医药卫生—外科学]