脑出血患者IL-6的表达及其临床意义  

The expression and significance of IL-6 in intracerebral hemorrhage

作　　者：杨延莉[1] 魏茂富[2] 刘镜文[2] 

机构地区：[1]广东省东莞市虎门医院内三科,广东东莞523900 [2]广东省东莞市虎门医院病理科,广东东莞523900

出　　处：《中国当代医药》2010年第3期24-25,共2页China Modern Medicine

摘　　要：目的:观察脑出血患者IL-6蛋白的表达情况,探讨IL-6蛋白在脑出血患者中表达特点与脑出血时间的关系和意义。方法:应用免疫组化方法检测65例脑出血患者出血灶周围脑组织IL-6蛋白的表达。结果:65例脑出血灶周边脑组织标本中,IL-6蛋白阳性表达率为92.3%(60/65),10例正常脑组织中IL-6蛋白阳性表达率为10%(1/10),两者比较,差异有统计学意义(P<0.01)。脑出血后<24h,IL-6蛋白阳性表达率为91.5%(43/47);出血后>24h,IL-6蛋白阳性表达率为94.4%(17/18);出血组之间比较,差异无统计学意义(P>0.05)。结论:IL-6参与了脑出血脑水肿的病理生理过程,而脑出血后脑水肿又导致IL-6浓度的异常变化,从而加重血肿周围脑组织的损害。Objective：To investigate the expression of IL-6 in intracerebral hemorrhage （IHC） and to find out its significance and its correlation with the time of intracerebral hemorrhage.Methods：The expression of IL-6 was assessed by immunohistochemistry staining.Results：In 65 cease of intracerebral hemorrhage, positive expression rate of IL-6 was 92.3% （60/65） and 10%（1/10） in normal brain tissues.The positive rate was significantly higher in intracerebral hemorrhage than in normal brain tissues（P0.01）.IL-6 positive expression rate was 91.5%（43/47） in 24 hours,and 94.4%（17/18） after 24 hours of intracerebral hemorrhage.IL-6 expression was irrelated with time of operation after intracerebral hemorrhage （P0.05）.Conclusion： IL-6 may be involved in the pathophysiologic process of brain edema after ICH brain edema, after ICH leads to the change of concentrations of IL-6 and aggravate brain damage around the hematoma.

关 键 词：IL-6蛋白 脑出血 免疫组化 

分 类 号：R743.34[医药卫生—神经病学与精神病学]