运动神经元疾病患者血清和脑脊液中GM1抗体的分布及其意义  

Serum and CSF antibody to GM1 ganglioside in patients with motor neuron disease

作　　者：金宇宣[1] 乔健[1] 吕传真[1] 

机构地区：[1]上海医科大学华山医院神经科

出　　处：《中华神经科杂志》1998年第5期281-284,共4页Chinese Journal of Neurology

摘　　要：目的分析运动神经元疾病（ＭＮＤ）患者血清和脑脊液中神经节苷脂（ＧＭ１）抗体的分布，研究其在ＭＮＤ发病过程中的作用。方法采用ＥＬＩＳＡ方法检测了４５例不同类型的ＭＮＤ患者血清和脑脊液中ＩｇＭＧＭ１、ＩｇＧＧＭ１抗体的水平。结果ＭＮＤ患者血清中ＩｇＭＧＭ１、ＩｇＧＧＭ１抗体均明显高于对照组，其中ＩｇＭＧＭ１抗体在进行性脊肌萎缩症患者中阳性率最高，而ＩｇＧＧＭ１抗体在ＭＮＤ的不同临床类型中差异无显著性意义。ＭＮＤ患者脑脊液中ＩｇＭＧＭ１和ＩｇＧＧＭ１抗体也均明显高于对照组（Ｐ＜０．０１），在ＭＮＤ不同临床类型中差异无显著性意义（Ｐ＞０．０５）。ＭＮＤ患者脑脊液中ＩｇＭＧＭ１和ＩｇＧＧＭ１抗体与血清中ＩｇＭＧＭ１和ＩｇＧＧＭ１抗体均不相关。结论ＭＮＤ患者周围和鞘内均存在对ＧＭ１的免疫反应，并可能参与了ＭＮＤ的发病过程。Objective To study the distribution of antibody against GM1 ganglioside in serum and CSF, and to probe into its pathogenetic role in motor neuron disease(MND). Method Using enzyme linked immunosorbent assays (ELISA), we examined the levels of serum and CSF antibody to GM1 Ganglioside in 45 patients with MND. Results The levels of serum IgM GM1 and IgG GM1 in the patients with MND were significantly higher than those in the normal controls( P <0.01). The frequency of IgM GM1 in the patients with progressive spinal muscular atrophy (PSMA) was significantly higher than that in the patients with other types of MND, but no difference for antibody to IgG GM1 in the patients with various types of MND( P >0.05). The results also indicated that the antibodies of IgM , IgG GM1 in CSF were not correlated to those in serum. Conclusion There are circulating and intrathecal humoral immune responses against GM1 in patients with MND. These humoral immune responses may play an important role in the pathogenesis of MND.

关 键 词：运动神经元疾病 脑脊液 GM1抗体 

分 类 号：R744.802[医药卫生—神经病学与精神病学]