喉癌患者血清可溶性白细胞介素-2受体和肿瘤坏死因子水平的研究  

Examination of serum soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-a (TNF-a) in patients with laryngeal cancinoma

作　　者：马玲国[1] 刘学仁[2] 

机构地区：[1]山西省人民医院耳鼻咽喉科,030012 [2]山西医科大学附属第二医院耳鼻咽喉科

出　　处：《耳鼻咽喉（头颈外科）》1998年第5期300-303,共4页Chinese Arch Otolaryngology-Head Neck Surg

摘　　要：应用单克隆、多克隆双抗体夹心ELISA检测了35例喉鳞癌患者的血清可溶性白细胞介素2受体(sIL-2R)和肿瘤坏死因子(7NF-α)水平。结果显示:喉癌患者sIL-2R水平较良性组或正常人显著升高(P<0.001),与喉癌临床分期、临床分型及淋巴结转移密切相关;喉癌患者7NF-α水平只有Ⅳ期显著高于良性组或正常人(P<0.05).提示:血清sIL-2R水平检测可作为喉癌诊断的一项辅助指标,并有助于了解喉癌的临床进程及生物学行为(如淋巴结转移等);TNF-α在介导喉癌的恶病质方面起重要作用。本文还探讨了血清sIL-2R水平在喉癌中升高的机理。The serum soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor-α (TNF-α) were measured with ELISA in 35 patients with laryngeal carcinoma (group A), 30 patients with laryngeal benign lesion (group B), and 25 healthy subjects (group C) from 1992 to 1993. Results showed that sIL-2R level was 487. 3 + 216. 3u/ml in group A, 202. 5±5. 540 u/ml in group B, and 181. 5± 63. 0 u/ml in group C. The comparison of group A with B and C showed significant difference (P<0. 001). The level of TNF-α was 248.5±116.5 pg/ml in group A, 169.3±44. 9 pg/ml in group B, and 191.3±57.8 pg/ml in group C. TNF-a level was 302. 3±111.83pg/ml only in patients with laryngeal carcinoma stage IV, which was significantly higher than that of healthy subjects (P<0. 05). The clinical significance of sIL-2R and TNF-a in laryngeal carcinoma was discussed.

关 键 词：喉肿瘤 IL-2 肿瘤坏死因子 

分 类 号：R739.650.3[医药卫生—肿瘤]